Lecture

Kinetic models: Enzyme Catalysis and Mass Action Laws

Description

This lecture by the instructor covers the principles of kinetic models in metabolism, focusing on enzyme catalysis and mass action laws. Topics include the lock-and-key and induced-fit models of enzyme-substrate interactions, the law of mass-action for reaction rates, examples of isomerization reactions, reversible and irreversible reactions, and the Michaelis-Menten kinetics. The lecture also delves into the simplification of kinetics through the Quasi-Steady-State Assumption (QSSA) and Quasi-Equilibrium Assumption (QEA). Furthermore, it explores the Hill kinetics, generalized mass action kinetics, and various types of enzyme regulation and inhibition mechanisms. The discussion extends to the Warburg Effect in cancer cells, computational studies on this effect, and the construction of kinetic models to describe it.

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