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This lecture explores the concept of mechanical stimulus in tissue remodeling, discussing scenarios of ACL rupture, external loading correlation, and the justification of mechanical stimulus descriptors. It delves into the relationship between bone density rate and mechanical stimulus, the effects of overuse and disuse on bone remodeling, and the importance of observing micro-damage. The application of finite element analysis in hip implant modeling is also covered, including geometry, constitutive laws, boundary conditions, and resolution steps. The lecture concludes with discussions on strain energy density, bone remodeling, and the evolution of density distribution around hip implants.