Genetic Compensation Mechanisms

This lecture explores the phenomenon of genetic compensation triggered by mutant mRNA degradation, as studied in zebrafish and mouse models. The instructor discusses the discrepancies between knockout and knockdown phenotypes, the role of CRISPR technology in gene function studies, and the transcriptional adaptation response triggered by unstable uncapped transcripts. The implications of these findings on human genetics are also discussed, highlighting how mutations affecting mRNA degradation can lead to milder disease phenotypes. Various molecular components involved in the transcriptional adaptation response are analyzed, shedding light on the underlying mechanisms and potential future research directions.