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This lecture discusses the Van Der Waals equation of state for real gases, which describes the behavior of real gases by modifying the assumptions made for ideal gases. The instructor explains the four key assumptions for deriving the theory of ideal gases and then introduces modifications for real gases, focusing on the volume of molecules and the interactions between them. By adjusting the volume and pressure calculations, the lecture leads to the derivation of the Van Der Waals equation of state, which accounts for the volume occupied by molecules and the attractive forces between them, providing a more accurate representation of real gas behavior.