This lecture covers various operating environments and their associated constraints relevant to mechanical systems. It begins with an overview of different environments such as vacuum, cryogenic, high temperature, radiative, and dusty environments. The instructor discusses the definitions and physical characteristics of these environments, including where they can be found and the mechanisms that operate within them. Specific attention is given to vacuum environments, detailing their pressure levels and effects on mechanical systems, such as lubrication issues and material outgassing. The lecture also addresses the challenges posed by radiative environments, including ionizing and non-ionizing radiation. The instructor emphasizes the importance of understanding these environments for the design and application of mechanical systems, highlighting the necessary standards and measures to ensure functionality and safety. The session concludes with a discussion on the implications of these extreme conditions on mechanical performance and reliability, providing a comprehensive understanding of the constraints faced in advanced mechanisms for extreme environments.