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This lecture delves into the convergence of social and biological determinants of health, exploring the implications of personalized health through epigenetics. Dr. Luca Chiapperino discusses the entanglement of bodies and their environments, the impact of maternal adversity on offspring, and the molecular traces of a bio-social continuum. The lecture also covers the plasticity of systems, the role of epigenetic dysregulation in neurobehavioral outcomes, and the use of epigenetic biomarkers for intervention and diagnosis.