Surfaces: Biomaterial Interactions and Modifications

This lecture covers the foreign body response to biomaterial implantation, implications of time on tissue response, surface modifications to control protein and cell interactions, passive versus active surfaces, cell adhesion mechanisms, nanotopography for stem cell interaction, non-fouling surface preparation, polymer coatings for antifouling, and the use of PEGylation to enhance surface properties. The concept of SLIPS (Slippery Liquid Infused Porous Surfaces) is also discussed, along with the Gecko Test. The instructor emphasizes the importance of engineered biomaterial surfaces in interacting with biological systems and the challenges faced due to the foreign-body response and coating defects.