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This lecture covers the implementation research (IR) in the context of improving dengue and Chagas disease prevention through eco-bio-social analysis and community-based intersectoral interventions. It discusses the challenges, strategies, and collaborative efforts involving various stakeholders, such as researchers, implementers, community members, and decision-makers. The lecture also delves into the specific case of Girardot, Colombia, where dengue is a significant health issue. The project stages, from situational diagnosis to the design and implementation of interventions, are outlined. Key outcomes, like the justification of water storage practices and the development of innovative strategies like anti-Aedes aegypti covers, are highlighted. The lecture emphasizes the importance of multi-component strategies, community engagement, and interdisciplinary collaboration in addressing complex health challenges.