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This lecture covers the concepts of reversibility, irreversibility, equilibrium, transport law, simple systems, and entropy. It discusses the behavior of isolated systems with fixed walls and varying states, emphasizing the importance of thermal equilibrium. The instructor explores the implications of homogeneous systems and the time required for thermalization. The lecture delves into the relationship between system homogeneity and thermal equilibrium, highlighting the thermalization process. It also addresses the thermal equilibrium of isolated systems with fixed substances and the thermalization time. The content progresses to discuss the thermal equilibrium of isolated systems with substances and the time required for thermalization.