This lecture covers the challenges and solutions in quantum and nanocomputing, focusing on cryogenic control, RF-reflectometry, characterization setups, limitations of room temperature control, power issues, spin-qubit quantum processors, Larmor frequency rotation of electrons, classical control for ESR and EDSR, case studies for single-qubit and two-qubit control and readout, derivations and methods for qubit state evolution, and the impact of classical control electronics on qubit fidelity.