MOOC
Simulation Neurocience
Description
Learn how to digitally reconstruct a single neuron to better study the biological mechanisms of brain function, behaviour and disease.
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Ontological neighbourhood
Instructor
Lectures in this MOOC (65)
Simulation Neuroscience: OverviewMOOC: Simulation Neurocience
Series introduces simulation neuroscience, covering neuron reconstruction, circuit building, and data organization.
Approaches and Rationale of Simulation NeuroscienceMOOC: Simulation Neurocience
Explores the overview, rationale, and strategies of simulation neuroscience, emphasizing the challenges of reconstructing and simulating the brain.
Principles of Simulation NeuroscienceMOOC: Simulation Neurocience
Covers the principles of Simulation Neuroscience, focusing on dense reconstruction from sparse data and iteratively reconstructing and testing models.
Data strategies: building neural circuitsMOOC: Simulation Neurocience
Explores data strategies for building neural circuits in simulation neuroscience.
Neuroinformatics StrategyMOOC: Simulation Neurocience
Explores the challenges of neuroinformatics and the importance of comparing experimental and simulation data for brain reconstructions.
Related concepts (310)
Chemical synapse
Chemical synapses are biological junctions through which neurons' signals can be sent to each other and to non-neuronal cells such as those in muscles or glands. Chemical synapses allow neurons to form circuits within the central nervous system. They are crucial to the biological computations that underlie perception and thought. They allow the nervous system to connect to and control other systems of the body. At a chemical synapse, one neuron releases neurotransmitter molecules into a small space (the synaptic cleft) that is adjacent to another neuron.
Action potential
An action potential occurs when the membrane potential of a specific cell rapidly rises and falls. This depolarization then causes adjacent locations to similarly depolarize. Action potentials occur in several types of animal cells, called excitable cells, which include neurons, muscle cells, and in some plant cells. Certain endocrine cells such as pancreatic beta cells, and certain cells of the anterior pituitary gland are also excitable cells.
Neuron
Within a nervous system, a neuron, neurone, or nerve cell is an electrically excitable cell that fires electric signals called action potentials across a neural network. Neurons communicate with other cells via synapses - specialized connections that commonly use minute amounts of chemical neurotransmitters to pass the electric signal from the presynaptic neuron to the target cell through the synaptic gap. The neuron is the main component of nervous tissue in all animals except sponges and placozoa.
Related courses (481)
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BIO-480: Neuroscience: from molecular mechanisms to disease
The goal of the course is to guide students through the essential aspects of molecular neuroscience and neurodegenerative diseases. The student will gain the ability to dissect the molecular basis of
Related publications (1,000)
A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits
Information is transmitted between brain regions through the release of neurotransmitters from long-range projecting axons. Understanding how the activity of such long-range connections contributes to behavior requires efficient methods for reversibly mani ...
Nature Portfolio2024Fear learning induces synaptic potentiation between engram neurons in the rat lateral amygdala
Henry Markram, Rodrigo de Campos Perin
The lateral amygdala (LA) encodes fear memories by potentiating sensory inputs associated with threats and, in the process, recruits 10-30% of its neurons per fear memory engram. However, how the local network within the LA processes this information and w ...
Nature Portfolio2024Cortical cell assemblies and their underlying connectivity: An in silico study
Michael Reimann, András Ecker, Sirio Bolaños Puchet, James Bryden Isbister, Daniela Egas Santander
Recent developments in experimental techniques have enabled simultaneous recordings from thousands of neurons, enabling the study of functional cell assemblies. However, determining the patterns of synaptic connectivity giving rise to these assemblies rema ...
2024