Publications by Nikolaos Stergiopoulos

Machine learning-enabled estimation of cardiac output from peripheral waveforms is independent of blood pressure measurement location in an in silico population

Nikolaos Stergiopoulos, Georgios Rovas, Lydia Aslanidou, Sokratis Anagnostopoulos

Monitoring of cardiac output (CO) is a mainstay of hemodynamic management in the acutely or critically ill patient. Invasive determination of CO using thermodilution, albeit regarded as the gold standard, is cumbersome and bears risks inherent to catheteri ...

2025

Testing an inverse modeling approach with gradient boosting regression for stroke volume estimation using patient thermodilution data

Nikolaos Stergiopoulos, Georgios Rovas, Vasiliki Bikia

Stroke volume (SV) is a major indicator of cardiovascular function, providing essential information about heart performance and blood flow adequacy. Accurate SV measurement is particularly important for assessing patients with heart failure, managing patie ...

FRONTIERS MEDIA SA2025

Evaluation of a novel compliance-matching aortic graft in a swine model

Nikolaos Stergiopoulos, Georgios Rovas, Vasiliki Bikia

The mismatch of elastic properties between the arterial tissue and the vascular grafts, commonly called compliance mismatch, is responsible for many deleterious post-operative complications. Currently, there is an absence of prostheses that conform with th ...

2025

The renin-angiotensin system in healthy human platelets: expressed but inactive

Nikolaos Stergiopoulos, François Cuenot

Platelets play a crucial role in arterial thrombus formation, offering potential for new antiplatelet therapies with reduced bleeding risk. Here, we investigated the role of the renin-angiotensin system (RAS) in human platelets and explored its potential l ...

Informa UK Limited2025

Left atrial wall shear stress correlates with fibrosis in patients with atrial fibrillation

Nikolaos Stergiopoulos, Georgios Rovas

Left atrial wall fibrosis has an important role in atrial fibrillation (AF) because of the abnormal electrophysiological properties of the fibrotic areas. However, the mechanisms behind the development of left atrial fibrosis are not well understood. Here, ...

Springer Science and Business Media LLC2025

Residual-based attention in physics-informed neural networks

Nikolaos Stergiopoulos, Sokratis Anagnostopoulos

Driven by the need for more efficient and seamless integration of physical models and data, physics -informed neural networks (PINNs) have seen a surge of interest in recent years. However, ensuring the reliability of their convergence and accuracy remains ...

Elsevier Science Sa2024

Local Shear Stress and Dyslipidemia Interfere with Actin Cyto-Skeleton and Lysosomal Organization Contributing to Vascular Fragility

Nikolaos Stergiopoulos, Rodrigo Araujo Fraga Da Silva

Shear stress is one of the major hemodynamic forces acting on the endothelium. However, it is not well known how endothelial cells (EC) respond mechanically to these stimuli in vivo. Here we investigated whether changes in biomechanics properties and shear ...

2024

Impact of arterial system alterations due to amputation on arterial stiffness and hemodynamics: a numerical study

Nikolaos Stergiopoulos

Subjects with amputation of the lower limbs are at increased risk of cardiovascular mortality and morbidity. We hypothesize that amputation-induced alterations in the arterial tree negatively impact arterial biomechanics, blood pressure and flow behavior. ...

Nature Research2024

Compliant vascular grafts and methods of use

Nikolaos Stergiopoulos, Georgios Rovas

Compliant vascular grafts for implantation in the vasculature are provided. The compliant vascular grafts are designed to expand longitudinally and radially within a blood vessel, such as an artery, and is expected to be particularly well suited for treati ...

2024

Novel theory and potential applications of central diastolic pressure decay time constant

Nikolaos Stergiopoulos, Georgios Rovas, Sokratis Anagnostopoulos, Vasiliki Bikia, Patrick Segers

Central aortic diastolic pressure decay time constant ( ) is according to the two-element Windkessel model equal to the product of total peripheral resistance (R) times total arterial compliance (C ). As such, it is related to arterial stiffness, which has ...

2024