Person
Horst Vogel
Related publications (248)
Structural heterogeneity of the ion and lipid channel TMEM16F
Transmembrane protein 16 F (TMEM16F) is a Ca2+-activated homodimer which functions as an ion channel and a phospholipid scramblase. Despite the availability of several TMEM16F cryogenic electron microscopy (cryo-EM) structures, the mechanism of activation ...
Berlin2024Method and system for determining intracellular mediators' activity
Philippe Renaud, Horst Vogel, Thamani Dahoun, Margaux Catherine Marie Duchamp
A method for determining the presence of a molecule coupled to the cytoplasmic side of a cellular membrane is disclosed. The method is implemented in a microfluidic setting and is particularly suitable for determining the presence and/or the activity of a ...
2022The role of metal ions in G protein-coupled receptor signalling and drug discovery
Horst Vogel, Shuguang Yuan, Xueying Wang
Metal ions, such as Na+, Mg2+, Ca2+, and Zn2+, are highly abundant in biological systems. For many G protein-coupled receptors (GPCRs), metal ions, especially Na+, have been found to stabilize the receptors' inactivate state preventing receptor activation. ...
WILEY2021Asymmetric opening of the homopentameric 5-HT3A serotonin receptor in lipid bilayers
Pentameric ligand-gated ion channels (pLGICs) of the Cys-loop receptor family are key players in fast signal transduction throughout the nervous system. They have been shown to be modulated by the lipid environment, however the underlying mechanism is not ...
NATURE RESEARCH2021Geosciences Roadmap for Research Infrastructures 2025–2028 by the Swiss Geosciences Community
Athanasios Nenes, Horst Vogel, Othmar Müntener, Lukas Baumgartner
This community roadmap presents an integrative approach including the most urgent infrastructure requests for the future development of geosciences in Switzerland. It recommends to strengthen the multidisciplinary nature of the geosciences by putting all a ...
Swiss Academy of Sciences (SCNAT)2021Enhancing the Signaling of GPCRs via Orthosteric Ions
G protein-coupled receptors play essential roles in cellular processes such as neuronal signaling, vision, olfaction, tasting, and metabolism. As GPCRs are the most important drug targets, understanding their interactions with ligands is of utmost importan ...
AMER CHEMICAL SOC2020Computational modeling of the olfactory receptor Olfr73 suggests a molecular basis for low potency of olfactory receptor-activating compounds
Horst Vogel, Horst Pick, Thamani Dahoun, Shuguang Yuan, Marc Brugarolas Campillos
The mammalian olfactory system uses hundreds of specialized G-protein-coupled olfactory receptors (ORs) to discriminate a nearly unlimited number of odorants. Cognate agonists of most ORs have not yet been identified and potential non-olfactory processes m ...
Springer2019New Binding Sites, New Opportunities for GPCR Drug Discovery
Horst Vogel, Thamani Dahoun, Shuguang Yuan, Yen-Huan Li
Many central biological events rely on protein-ligand interactions. The identification and characterization of protein-binding sites for ligands are crucial for the understanding of functions of both endogenous ligands and synthetic drug molecules. G prote ...
ELSEVIER SCIENCE LONDON2019Advancing Drug Discovery via Artificial Intelligence
Horst Vogel, Thamani Dahoun, Shuguang Yuan
Drug discovery and development are among the most important translational science activities that contribute to human health and wellbeing. However, the development of a new drug is a very complex, expensive, and long process which typically costs 2.6 bill ...
ELSEVIER SCIENCE LONDON2019Single-Vesicle Assays Using Liposomes and Cell-Derived Vesicles: From Modeling Complex Membrane Processes to Synthetic Biology and Biomedical Applications
Horst Vogel, Horst Pick, Ana Catarina Rodrigues Alves
The plasma membrane is of central importance for defining the closed volume of cells in contradistinction to the extracellular environment. The plasma membrane not only serves as a boundary, but it also mediates the exchange of physical and chemical inform ...
AMER CHEMICAL SOC2018