Florian Maria Wurm

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Related publications (117)

Analysis of volumetric mass transfer coefficient (k(L)a) in small- (250 mL) to large-scale (2500 L) orbitally shaken bioreactors

Florian Maria Wurm, David Hacker, Likuan Zhu

In this study, the combination of dimensional analysis (DA) and analysis of variance (ANOVA) was used to predict the volumetric mass transfer coefficient (k(L)a) values under different operating conditions for orbitally shaken bioreactors (OSRs) with diffe ...

SPRINGER HEIDELBERG2020

Trimeric SARS-CoV-2 Spike Proteins Produced from CHO Cells in Bioreactors Are High-Quality Antigens

Florian Maria Wurm

The spike protein of the pandemic human corona virus is essential for its entry into human cells. In fact, most neutralizing antibodies against Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) are directed against the Virus-surface exposed spi ...

2020

The Delivery of alpha 1-Antitrypsin Therapy Through Transepidermal Route: Worthwhile to Explore

Florian Maria Wurm

Human alpha 1-antitrypsin (AAT) is an abundant acute phase glycoprotein expressing anti-protease and immunomodulatory activities, and is used as a biopharmaceutical to treat patients with inherited AAT deficiency. The pleiotropic properties of AAT provide ...

FRONTIERS MEDIA SA2020

Designs and Characterization of Subunit Ebola GP Vaccine Candidates: Implications for Immunogenicity

Florian Maria Wurm, Bruno Emanuel Ferreira De Sousa Correia, Sarah Wehrle, Divor Kiseljak

The humoral responses of Ebola virus (EBOV) survivors mainly target the surface glycoprotein GP, and anti-GP neutralizing antibodies have been associated with protection against EBOV infection. In order to elicit protective neutralizing antibodies through ...

FRONTIERS MEDIA SA2020

Recombinant Proteins for Industrial versus Pharmaceutical Purposes: A Review of Process and Pricing

Florian Maria Wurm

Recombinant proteins have been produced for over 30 years. Applications range from enzymes used in laundry detergents to antigen-detecting antibodies in cancer therapy. Despite similarities in manufacturing, drastic differences in retail pricing between re ...

2019

Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

Florian Maria Wurm, Bernard Schneider, Vivianne Padrun, Nicole Déglon, Daniel Roman Blessing, Gabriel Vachey

Adeno-associated virus (AAV) vectors are currently among the most commonly applied for in vivo gene therapy approaches. The evaluation of vectors during clinical development requires the production of considerable amounts of highly pure and potent vectors. ...

2019

Sensitivity of the SHiP experiment to Heavy Neutral Leptons

Lesya Shchutska, Aurelio Bay, Elena Graverini, Guido Haefeli, Florian Maria Wurm, Mikhail Chapochnikov, Alexey Boyarsky, Sun Hee Kim, Federico Leo Redi, Oleg Ruchayskiy

Heavy Neutral Leptons (HNLs) are hypothetical particles predicted by many extensions of the Standard Model. These particles can, among other things, explain the origin of neutrino masses, generate the observed matter-antimatter asymmetry in the Universe an ...

Springer Nature2019

Improved process conditions for increasing expression of MHC class II protein from a stable Drosophila S2 cell line

Florian Maria Wurm, David Hacker, Lucia Baldi Unser, Xiao Shen

2018

Design and characterization of near-native Ebola GP vaccine candidates: implications for immunogenicity

Florian Maria Wurm, François Gallaire, Bruno Emanuel Ferreira De Sousa Correia, Giancarlo Corradini, Sarah Wehrle

E M H SWISS MEDICAL PUBLISHERS LTD2018

Fluid dynamics of flow fields in a disposable 600-mL orbitally shaken bioreactor

Florian Maria Wurm, David Hacker, Dominique Terry Monteil Jr, Likuan Zhu

Orbitally shaken bioreactors (OSRs) are commonly used for the cultivation of mammalian cells in suspension. Here we conducted a three-dimensional computational fluid dynamics (CFD) simulation to characterize the fluid field in the disposable 600-mL orbital ...

Elsevier2018

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Analysis of volumetric mass transfer coefficient (k(L)a) in small- (250 mL) to large-scale (2500 L) orbitally shaken bioreactors

Florian Maria Wurm, David Hacker, Likuan Zhu

SPRINGER HEIDELBERG2020