Person
Sylvain Eric Lengacher
This person is no longer with EPFL
Related publications (21)
Control of Mitochondrial pH by Uncoupling Protein 4 in Astrocytes Promotes Neuronal Survival
Pierre Magistretti, Hélène Danielle Perreten Lambert, Sylvain Eric Lengacher, Manuel Raphael Zenger, Jean-Yves Chatton
Brain activity is energetically costly and requires a steady and highly regulated flow of energy equivalents between neural cells. It is believed that a substantial share of cerebral glucose, the major source of energy of the brain, will preferentially be ...
American Society for Biochemistry and Molecular Biology2014The human CFTR protein expressed in CHO cells activates aquaporin-3 in a cAMP-dependent pathway: study by digital holographic microscopy
Pierre Magistretti, Pierre Marquet, Sylvain Eric Lengacher, Pascal Jourdain
The transmembrane water movements during cellular processes and their relationship to ionic channel activity remain largely unknown. As an example, in epithelial cells it was proposed that the movement of water could be directly linked to cystic fibrosis t ...
Company of Biologists2014Resistance to Diet-Induced Obesity and Associated Metabolic Perturbations in Haploinsufficient Monocarboxylate Transporter 1 Mice
Pierre Magistretti, Sylvain Eric Lengacher, Luc Pellerin
The monocarboxylate transporter 1 (MCT1 or SLC16A1) is a carrier of short-chain fatty acids, ketone bodies, and lactate in several tissues. Genetically modified C57BL/6J mice were produced by targeted disruption of the mct1 gene in order to understand the ...
Public Library of Science2013Astrocyte–neuron co-culture on microchips based on the model of SOD mutation to mimic ALS
Philippe Renaud, Pierre Magistretti, Patrick Aebischer, Sylvain Eric Lengacher, Anja Kunze, Elisabeth Anne Dirren
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease. ALS is believed to be a non-cell autonomous condition, as other cell types, including astrocytes, have been implicated in disease pathogenesis. Hence, to facilitate the developmen ...
Royal Soc Chemistry2013Oligodendroglia metabolically support axons and contribute to neurodegeneration
Yiming Li, Pierre Magistretti, Sylvain Eric Lengacher, Luc Pellerin, Lin Jin
Oligodendroglia support axon survival and function through mechanisms independent of myelination, and their dysfunction leads to axon degeneration in several diseases. The cause of this degeneration has not been determined, but lack of energy metabolites s ...
2012Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function
Patrick Aebischer, Bernard Schneider, Sylvain Eric Lengacher, Julien Dusonchet
Mitochondrial dysfunction and oxidative stress have been implicated in the etiology of Parkinsons disease. Therefore, pathways controlling mitochondrial activity rapidly emerge as potential therapeutic targets. Here, we explore the neuronal response to pro ...
Oxford University Press2012Glutamate transport decreases mitochondrial pH and modulates oxidative metabolism in astrocytes
Hélène Danielle Perreten Lambert, Sylvain Eric Lengacher, Jean-Yves Chatton
During synaptic activity, the clearance of neuronally released glutamate leads to an intracellular sodium concentration increase in astrocytes that is associated with significant metabolic cost. The proximity of mitochondria at glutamate uptake sites in as ...
2011Quantitative rt-PCR analysis of uncoupling protein isoforms in mouse brain cortex: methodological optimization and comparison of expression with brown adipose tissue and skeletal muscle
Pierre Magistretti, Sylvain Eric Lengacher, Luc Pellerin
Uncoupling proteins (UCPs) present in the inner mitochondrial membrane are involved in uncoupling respiration from ATP synthesis. Five UCP isoforms have been identified but information about their presence and level of expression in the central nervous sys ...
2004Early acquisition of typical metabolic features upon differentiation of mouse neural stem cells into astrocytes
Pierre Magistretti, Sylvain Eric Lengacher, Luc Pellerin, Jean-Yves Chatton
Specific metabolic features, such as glutamate reuptake, have been associated with normal functions of mature astrocytes. In this study, we examined whether these characteristics are acquired together with classical phenotypic markers of differentiated ast ...
2004Cell-specific expression pattern of monocarboxylate transporters in astrocytes and neurons observed in different mouse brain cortical cell cultures
Pierre Magistretti, Sylvain Eric Lengacher, Luc Pellerin
Evidence suggests that lactate could be a preferential energy substrate transferred from astrocytes to neurons. Such a process implies the presence of specific monocarboxylate transporters on both cell types. Expression of MCT1 and MCT2, two isoforms of th ...
2003