Alke Fink

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Related publications (48)

Enhancement of the efficiency of non-viral gene delivery by application of pulsed magnetic field

Heinrich Hofmann, Alke Fink, Benedikt Steitz

New approaches to increase the efficiency of non-viral gene delivery are still required. Here we report a simple approach that enhances gene delivery using permanent and pulsating magnetic fields. DNA plasmids and novel DNA fragments (PCR products) contain ...

2006

Plastic Micropump with ferrofluidic actuation

Martinus Gijs, Heinrich Hofmann, Virendra Kumar Parashar, Alke Fink, Christophe Yamahata, Mathieu Chastellain

Institute of Electrical and Electronics Engineers2005

Intraarticular application of superparamagnetic nanoparticles and their uptake by synovial membrane—an experimental study in sheep

Heinrich Hofmann, Alke Fink, Benedikt Steitz, Mathieu Chastellain

A superparamagnetic iron oxide nanoparticle, coated with polyvinyl alcohol, (PVA-SPION) and its fluorescently functionalized analogue (amino-PVA-Cy3.5-SPION) were compared in vivo as proof of principle for future use in magnetic drug targeting in inflammat ...

2005

Methodology description for detection of cellular uptake of PVA coated superparamagnetic iron oxide nanoparticles (SPION) in synovial cells of sheep

Heinrich Hofmann, Alke Fink, Mathieu Chastellain

The detection of superparamagnetic iron oxide nanoparticles (SPION) in synoviocytes is reported. Synoviocytes were incubated for 2, 12, 24 and 48 h with 1.5 mg/ml of PVA coated SPION under the influence of magnets (12 h). Particles were well tolerated by t ...

2005

Development of biocompatible functionalized superparamagnetic iron oxide nanoparticles for human cancer cell uptake and intracellular delivery

Heinrich Hofmann, Alke Fink, Alessio Ferrari, Mathieu Chastellain

2005

Particle size investigations of a multistep synthesis of PVA coated superparamagnetic nanoparticles

Heinrich Hofmann, Alke Fink, Mathieu Chastellain

Nanoscaled particles showing superparamagnetic behavior have been intensively studied in the past years for various applications. Nevertheless, the lack of well-defined particles remains an important problem. One of the major challenges is still the large- ...

2004