Mikaël Martino

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Related publications (39)

Engineering the Regenerative Microenvironment with Biomaterials

Jeffrey Alan Hubbell, Mikaël Martino, Priscilla Suhasna Maithili Briquez, Federico Tortelli, Jeffrey James Rice

Modern synthetic biomaterials are being designed to integrate bioactive ligands within hydrogel scaffolds for cells to respond and assimilate within the matrix. These advanced biomaterials are only beginning to be used to simulate the complex spatio-tempor ...

Wiley-Blackwell2013

Exploring the growth factor-binding properties of osteopontin

Jeffrey Alan Hubbell, Mikaël Martino, Federico Tortelli

Wiley-Blackwell2012

Dose- and time-dependent angiogenesis by controlled delivery of matrix-bound VEGF

Jeffrey Alan Hubbell, Veronica Sacchi, Mikaël Martino, Elena Groppa

Wiley-Blackwell2012

Engineering of Signaling Microenvironments with Fibronectin Domains to Enhance Tissue Regeneration

Mikaël Martino

Conducting tissue healing and regeneration through biomaterials and morphogens is still an unrealized goal. Understand the multiple roles of the extracellular matrix (ECM) is indeed essential for the design of successful regenerative medicine strategies. D ...

EPFL2011

Engineering the growth factor microenvironment with fibronectin domains to promote wound and bone tissue healing

Jeffrey Alan Hubbell, Mikaël Martino, Federico Tortelli, Mayumi Mochizuki Martino

Although growth factors naturally exert their morphogenetic influences within the context of the extracellular matrix microenvironment, the interactions among growth factors, their receptors, and other extracellular matrix components are typically ignored ...

2011

PPS nanoparticles as versatile delivery system to induce systemic and broad mucosal immunity after intranasal administration

Jeffrey Alan Hubbell, Eleonora Simeoni, Melody Swartz, Mikaël Martino, Armando Stano

Degradable polymer nanoparticles (NPs, 50nm) based on polypropylene sulfide (PPS) were conjugated to thiolated antigen and adjuvant proteins by reversible disulfide bonds and evaluated in mucosal vaccination. Ovalbumin was used as a model antigen, and anti ...

Elsevier2011

Biomimetic materials in tissue engineering

Jeffrey Alan Hubbell, Mikaël Martino, Jennifer Patterson

Biomaterial matrices are being developed that mimic the key characteristics of the extracellular matrix, including presenting adhesion sites and displaying growth factors in the context of a viscoelastic hydrogel. This review focuses on two classes of mate ...

Elsevier2010

Recombinant FGF-18 with a collagen II binding domain prevents cartilage degeneration in mice over five weeks after two intra-articular injections

Jeffrey Alan Hubbell, Mikaël Martino, Dominique André Rothenfluh

2009

Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability

Jeffrey Alan Hubbell, Mikaël Martino, Dominique André Rothenfluh, Thomas Barker, Mayumi Mochizuki Martino

The extracellular matrix (ECM) exerts powerful control over many cellular phenomena, including stem cell differentiation. As such, design and modulation of ECM analogs to ligate specific integrin is a promising approach to control cellular processes in vit ...

Elsevier2008

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