Person
Loay Awad
This person is no longer with EPFL
Related publications (9)
Synthesis of chemical tools to improve water solubility and promote the delivery of salinomycin to cancer cells
Chemotherapy and radiation are unable to eliminate all cancer cells, particularly apoptosis-resistant cancer cells, despite their ability to kill cancer cluster cells. Thus, it is important to identify methods that eliminate all cancer cells in order to pr ...
SPANDIDOS PUBL LTD2020Seasonal and spatial variation in total trihalomethane formation potential in groundwater in Tulkarm and Hebron, Palestine
Water disinfection using processes such as chlorination is required to kill bacteria and harmful biological components. During chlorination, organic components in water react with chlorine, forming harmful disinfection by-products such as trihalomethanes ( ...
SPRINGER HEIDELBERG2019A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides
Hilal Lashuel, Loay Awad, Ritwik Burai, Nino Jejelava
We present the design, synthesis, and characterization of a novel photocaged glutamine derivative (modified on the side chain of glutamine), and describe its use in enhancing peptide stability and solubility. Our results demonstrate that this approach can ...
Wiley-Blackwell2016Chemical strategies for controlling protein folding and elucidating the molecular mechanisms of amyloid formation and toxicity
Hilal Lashuel, Bruno Claude Daniel Fauvet, Loay Awad, Mirva Hejjaoui
It has been more than a century since the first evidence linking the process of amyloid formation to the pathogenesis of Alzheimer's disease. During the last three decades in particular, increasing evidence from various sources (pathology, genetics, cell c ...
Elsevier2012Rational Design of Indoleamine 2,3-Dioxygenase Inhibitors
Pierre Vogel, Loay Awad, Olivier Michielin
Indoleamine 2,3-dioxygenase (IDO) is an important therapeutic target for the treatment of diseases such as cancer that involve pathological immune escape. We have used the evolutionary docking algorithm EADock to design new inhibitors of this enzyme. First ...
2010Synthesis of a C-linked disaccharide analogue of the Thomsen Friedenreich (TF)-epitope a-O-conjugated to L-serine and formation of a cluster as potential anticancer vaccine
Cell surface glycoproteins and glycolipids are responsible for cellular recognition processes. Vaccination is the procedure whereby the immune system is induced to create antibodies against a foreign molecule involved in disease or viral infection. In many ...
EPFL2005Silyl methallylsulfinates: efficient and powerful agents for the chemoselective silylation of alcohols, polyols, phenols and carboxylic acids
Pierre Vogel, Loay Awad, Cotinica Craita, Xiaogen Huang
Alcohols, phenols and carboxylic acids are silylated with very good yields in the presence of silyl methallylsulfinates under non- basic conditions and with the formation of volatile co-products. ...
2005C-linked disaccharide analogue of the Thomsen-Friedenreich (T)-epitope alpha-O-conjugated to L-serine
Condensation of a silylated beta-D-galactopyranosylaldehyde (3) with isolevoglucosenone (4) in the presence of Et(2)AII provided bicyclic enone 5. Subsequent addition of BnNHOMe gave adduct 6, which was converted into 4-O-acetyl-1,6-anhydro-3-C-[ R)1.3,4,5 ...
2005Synthesis of C-linked analogues of beta-D-galactopyranosyl-(1 -> 3)-D-galactopyranosides and of beta-D-galactopyranosyl-(1 -> 3)-D-galactal
Pierre Vogel, Loay Awad, Raynald Demange
C-linked disaccharide derivatives mimicking O-beta-D-galactopyranosyl-(1-->3)-D-galactopyranosides (end groups in Core-B structures of biologically important proteoglycans) have been obtained from isolevoglucosenone and beta-D-galactopyranosylcarbaldehyde ...
2004