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A review with 35 refs. Creating functional biol. mols. de novo requires a detailed understanding of the intimate relationship between primary sequence, folding mechanism, and packing topol., and remains up to now a most challenging goal in protein design a ...
Pseudo-proline building blocks exert a dual functionality in enhancing and stabilizing the relevant polyproline II (PPII) conformation and increasing and optimizing van der Waals contacts and hydrogen bonding to the receptor mols. thus modifying affinity a ...
Tyrosine sulfation and O-glycosylation are two post-translational modifications playing an essential role in modulation of biol. activity, protein folding and cellular communication. Here, a novel chem. approach for the synthesis of biotinylated glycosulfo ...