Person
Simone Cavadini
This person is no longer with EPFL
Related publications (9)
Structural mechanism of cGAS inhibition by the nucleosome
Rudolf Hovius, Beat Fierz, Andrea Ablasser, Baptiste Claude André Guey, Alexiane Clara Decout, Pauline Ambre Melenec, Simone Cavadini, Kristina Makasheva, Sélène-Véronique Glück
The DNA sensor cGAS initiates innate immune responses following microbial infection, cellular stress, and cancer1. Upon activation by double-stranded DNA, cytosolic cGAS produces 2’3’ cyclic GMP-AMP and triggers inflammatory cytokine and type I interferon ...
2020Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome
Henning Paul-Julius Stahlberg, Simone Cavadini, Radosav Svetozara Pantelic
The cullin-RING ubiquitin E3 ligase (CRL) family comprises over 200 members in humans. The COP9 signalosome complex (CSN) regulates CRLs by removing their ubiquitin-like activator NEDD8. The CUL4A-RBX1-DDB1-DDB2 complex (CRL4A(DDB2)) monitors the genome fo ...
Springer Nature2016Line-narrowing in proton-detected nitrogen-14 NMR
Geoffrey Bodenhausen, Simone Cavadini, Simone Ulzega
In solids spinning at the magic angle, the indirect detection of single-quantum (SQ) and double-quantum (DQ) N-14 spectra (l = 1) via spy nuclei S = 1/2 such as protons can be achieved in the manner of heteronuclear single- or multiple-quantum correlation ...
2010Indirect detection of nitrogen-14 in solid-state NMR spectroscopy
This thesis describes new methods for the detection of 14N nuclei by solid-state nuclear magnetic resonance. So far, the low natural abundance (0.4 %) 15N isotope has been widely used to study nitrogen-containing samples because of its spin-1/2 nature. The ...
EPFL2009Micelles for delivery of nitric oxide
Nikolaos Stergiopoulos, Davide Demurtas, Jeffrey Alan Hubbell, Simone Cavadini, Tyler Nerton Thacher, Yun Suk Jo, Jay Gantz
We designed block copolymer pro-amphiphiles and amphiphiles for providing very long-term release of nitric oxide (NO). A block copolymer of N-acryloylmorpholine (AM, as a hydrophile) and N-acryloyl-2,5-dimethylpiperazine (AZd, as a hydrophilic precursor) w ...
2009Singlet states open the way to longer time-scales in the measurement of diffusion by NMR spectroscopy
Paul Romeo Vasos, Simone Cavadini
Nuclear magnetic resonance is a powerful nonintrusive technique for measuring diffusion coefficients through the use of pulsed field gradients. The main limitation to the application range of this method is imposed by the relaxation time constants of the m ...
2008Coherence transfer between spy nuclei and nitrogen-14 in solids
Geoffrey Bodenhausen, Simone Cavadini
Coherence transfer from ‘spy nuclei’ such as 1H or 13C (S = 1/2) was used to excite single- or double-quantum coherences of 14N nuclei (I = 1) while the S spins were aligned along the static field, in the manner of heteronuclear single-quantum correlation ...
2008Evidence for Dynamics on a 100 ns Time Scale from Single- and Double-Quantum Nitrogen-14 NMR in Solid Peptides
Geoffrey Bodenhausen, Simone Cavadini, Simone Ulzega
The indirect detection of 14N spectra via protons in the manner of heteronuclear multiple-quantum correlation (HMQC) allows one to obtain single- (SQ) and double-quantum (DQ) 14N spectra in solids. A comparison of the SQ and DQ line widths as a function of ...
2008Slow Diffusion by Singlet State NMR Spectroscopy
Geoffrey Bodenhausen, Simone Cavadini
Small diffusion coeffs. can be measured by using populations of singlet states that have a relaxation time const., Ts, which can be much longer than the longitudinal relaxation time, T1. Spatial information can be encoded with pulsed field gradients in the ...
2005