Publications by Nicole Déglon

Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments

Graham Knott, Corrado Cali, Nicole Déglon, Tamara Zehnder, Luca Pucci, Andrea Chicca

Astrocytes orchestrate neural development by powerfully coordinating synapse formation and function and, as such, may be critically involved in the pathogenesis of neurodevelopmental abnormalities and cognitive deficits commonly observed in psychiatric dis ...

2020

Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

Florian Maria Wurm, Bernard Schneider, Vivianne Padrun, Daniel Roman Blessing, Gabriel Vachey, Nicole Déglon

Adeno-associated virus (AAV) vectors are currently among the most commonly applied for in vivo gene therapy approaches. The evaluation of vectors during clinical development requires the production of considerable amounts of highly pure and potent vectors. ...

2019

Connexin 30 sets synaptic strength by controlling astroglial synapse invasion

Graham Knott, Nicole Déglon

Astrocytes play active roles in brain physiology by dynamic interactions with neurons. Connexin 30, one of the two main astroglial gap-junction subunits, is thought to be involved in behavioral and basic cognitive processes. However, the underlying cellula ...

Nature Publishing Group2014

Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons

Ozgün Gökce, Nikita Rudinskiy, Nicole Déglon

Hippocalcin is a neuronal calcium sensor protein previously implicated in regulating neuronal viability and plasticity. Hippocalcin is the most highly expressed neuronal calcium sensor in the medium spiny striatal output neurons that degenerate selectively ...

Wiley-Blackwell2009

Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry

Patrick Aebischer, Ozgün Gökce, Heike Runne, Nicole Déglon, Diana Zala

Gene expression changes are a hallmark of the neuropathology of Huntington's disease (HD), but the exact molecular mechanisms of this effect remain uncertain. Here, we report that in vitro models of disease comprised of primary striatal neurons expressing ...

2008

Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease

Nicole Déglon

Machado-Joseph disease (MJD) is a fatal, dominant neurodegenerative disorder. MJD results from polyglutamine repeat expansion in the MJD-1 gene, conferring a toxic gain of function to the ataxin-3 protein. In this study, we aimed at overexpressing ataxin-3 ...

Oxford University Press2008

Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease

Patrick Aebischer, Nicole Déglon

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an expansion of glutamine repeats in the huntingtin (htt) protein. Abnormal protein folding and the accumulation of mutated htt are hallmarks of HD neuropathology. Heat-shock pr ...

Elsevier2007

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Nicole Déglon

Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments

Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

Connexin 30 sets synaptic strength by controlling astroglial synapse invasion

Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons

Sustained Effects of Nonallele-Specific Huntingtin Silencing

Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry

Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease

Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo

Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease

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Chat with Graph Search

Connexin 30 sets synaptic strength by controlling astroglial synapse invasion

Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments

Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry

Sustained Effects of Nonallele-Specific Huntingtin Silencing

Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease

Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease

Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons

Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo