Sandor Kasas

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Environmental Control of Amyloid Polymorphism by Modulation of Hydrodynamic Stress

Giovanni Dietler, François Gallaire, Sandor Kasas, Serguei Sekatski, Ludovic Pierre Gustave Keiser, Jiangtao Zhou, Leonardo Venturelli

The phenomenon of amyloid polymorphism is a key feature of protein aggregation. Unravelling this phenomenon is of great significance for understanding the underlying molecular mechanisms associated with neurodegenerative diseases and for the development of ...

AMER CHEMICAL SOC2021

Nanomechanical bio-sensing for fast and reliable detection of viability and susceptibility of microorganisms

Giovanni Dietler, Sandor Kasas, María Inés Villalba, Leonardo Venturelli, Raphaël Foschia

The metabolic activity of living organisms results in cellular motion on a nanometric scale that can be efficiently detected by micro- and nano- fabricated sensors. Quartz crystal microbalance and atomic force microscopy (AFM) inspired techniques have rece ...

2021

Nano-Motion Analysis for Rapid and Label Free Assessing of Cancer Cell Sensitivity to Chemotherapeutics

Sandor Kasas, María Inés Villalba, Petar Stupar

Background and Objectives: Optimization of chemotherapy is crucial for cancer patients. Timely and costly efficient treatments are emerging due to the increasing incidence of cancer worldwide. Here, we present a methodology of nano-motion analysis that cou ...

2021

Nanomotion Detection-Based Rapid Antibiotic Susceptibility Testing

Sandor Kasas, María Inés Villalba, Anton Malovichko

Rapid antibiotic susceptibility testing (AST) could play a major role in fighting multidrug-resistant bacteria. Recently, it was discovered that all living organisms oscillate in the range of nanometers and that these oscillations, referred to as nanomotio ...

2021

Nanomotion Spectroscopy as a New Approach to Characterize Bacterial Virulence

Giovanni Dietler, Sandor Kasas, María Inés Villalba, Giovanni Longo, Leonardo Venturelli

Atomic force microscopy (AFM)-based nanomotion detection is a label-free technique that has been used to monitor the response of microorganisms to antibiotics in a time frame of minutes. The method consists of attaching living organisms onto an AFM cantile ...

MDPI2021

Yeast Nanometric Scale Oscillations Highlights Fibronectin Induced Changes in C. albicans

Giovanni Dietler, Sandor Kasas, Anne-Céline Verenna Kohler, Leonardo Venturelli

Yeast resistance to antifungal drugs is a major public health issue. Fungal adhesion onto the host mucosal surface is still a partially unknown phenomenon that is modulated by several actors among which fibronectin plays an important role. Targeting the ye ...

2020

A perspective view on the nanomotion detection of living organisms and its features

Giovanni Dietler, Sandor Kasas, Anne-Céline Verenna Kohler, María Inés Villalba, Petar Stupar, Giovanni Longo, Leonardo Venturelli, Massimiliano Bertacchi

The insurgence of newly arising, rapidly developing health threats, such as drug-resistant bacteria and cancers, is one of the most urgent public-health issues of modern times. This menace calls for the development of sensitive and reliable diagnostic tool ...

WILEY2020

Adaptation of Pseudomonas aeruginosa to constant sub-inhibitory concentrations of quaternary ammonium compounds

Urs von Gunten, Giovanni Dietler, Sandor Kasas, Florian Frédéric Vincent Breider, Leonardo Venturelli, Myriam Borgatta, Margaux Océane Voumard

Quaternary ammonium compounds (QACs) are widely used in consumer products for disinfection purposes. QACs are frequently detected in aquatic systems at sub-inhibitory concentrations and were found to affect the development of antimicrobial resistance if ba ...

2020

Single yeast cell nanomotions correlate with cellular activity

Giovanni Dietler, Sandor Kasas, María Inés Villalba, Anton Malovichko

Living single yeast cells show a specific cellular motion at the nanometer scale with a magnitude that is proportional to the cellular activity of the cell. We characterized this cellular nanomotion pattern of nonattached single yeast cells using classical ...

AMER ASSOC ADVANCEMENT SCIENCE2020

Advanced technological tools to study multidrug resistance in cancer

Sandor Kasas

The complexity of cancer biology and its clinical manifestation are driven by genetic, epigenetic, transcriptomic, proteomic and metabolomic alterations, supported by genomic instability as well as by environmental conditions and lifestyle factors. Althoug ...

CHURCHILL LIVINGSTONE2020

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