Darlene Goldstein

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Related publications (21)

Comprehensive analysis of Arabidopsis expression polymorphisms with simple inheritance

In Arabidopsis thaliana, gene expression level polymorphisms (ELPs) between natural accessions that exhibit simple, single locus inheritance are promising quantitative trait locus (QTL) candidates to explain phenotypic variability. It is assumed that such ...

2009

Selecting control genes for RT-QPCR using public microarray data

Darlene Goldstein, Mauro Delorenzi, Vlad Popovici

Background: Gene expression analysis has emerged as a major biological research area, with real-time quantitative reverse transcription PCR (RT-QPCR) being one of the most accurate and widely used techniques for expression profiling of selected genes. In o ...

2009

Proteogenomic studies in epithelial ovarian cancer: established knowledge and future needs

Darlene Goldstein

There has been a concerted effort over the last decade to improve our understanding of the complex biology of ovarian cancer. A linear growth in published proteogenomic studies has addressed a variety of questions regarding its molecular pathogenesis. A nu ...

2009

Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures

Darlene Goldstein, Mauro Delorenzi, Thierry Sengstag, Benjamin Haibe-Kains

Introduction Breast cancer subtyping and prognosis have been studied extensively by gene expression profiling, resulting in disparate signatures with little overlap in their constituent genes. Although a previous study demonstrated a prognostic concordance ...

2008

Quality Assessment for Short Oligonucleotide Microarray Data: Comment

Darlene Goldstein

American Statistical Association2008

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

Darlene Goldstein, Mauro Delorenzi, Thierry Sengstag

To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage have important effects on disease-related transcriptional dysfunction, we compared the changes in mRNA in seven genetic mouse models of Huntington's disease (HD) a ...

Oxford University Press2007

Modulation of nucleosome dynamics in Huntington's disease

Darlene Goldstein

Oxford University Press2007

Regional and cellular gene expression changes in human Huntington's disease brain

Darlene Goldstein, Mauro Delorenzi, Doris Chau Voo Thu, Thierry Sengstag

Huntington's disease (HD) pathology is well understood at a histological level but a comprehensive molecular analysis of the effect of the disease in the human brain has not previously been available. To elucidate the molecular phenotype of HD on a genome- ...

Oxford University Press2006

Partition resampling and extrapolation averaging: approximation methods for quantifying gene expression in large numbers of short oligonucleotide arrays

Darlene Goldstein

Oxford, Oxford University Press2006

A Laplace mixture model for the identification of differential expression in microarrays

Anthony Christopher Davison, Darlene Goldstein, Yann Ruffieux

Microarrays have become an important tool for studying the molecular basis of complex disease traits and fundamental biological processes. A common purpose of microarray experiments is the detection of genes that are differentially expressed under two cond ...

2006

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