Publications by Benjamin Blasco

Functional Dissection of Intersubunit Interactions in the EspR Virulence Regulator of Mycobacterium tuberculosis

Giovanni Dietler, Stewart Cole, Aleksandre Japaridze, Matteo Dal Peraro, Florence Pojer, Marco Stenta, Benjamin Blasco, Basile Isidore Martin Wicky

The nucleoid-associated protein EspR, a chromosome organizer, has pleiotropic effects on expression of genes associated with cell wall function and pathogenesis in Mycobacterium tuberculosis. In particular, EspR binds to several sites upstream of the espAC ...

American Society for Microbiology2014

Structure-function analysis of the EspR virulence regulator of Mycobacterium tuberculosis

Benjamin Blasco

EPFL2014

Virulence Regulator EspR of Mycobacterium tuberculosis Is a Nucleoid-Associated Protein

Stewart Cole, Florence Pojer, Jacques Rougemont, Claudia Sala, Ruben Hartkoorn, Swapna Uplekar, Benjamin Blasco, Jeffrey Chen

The principal virulence determinant of Mycobacterium tuberculosis (Mtb), the ESX-1 protein secretion system, is positively controlled at the transcriptional level by EspR. Depletion of EspR reportedly affects a small number of genes, both positively or neg ...

Public Library of Science2012

Towards anti-virulence drugs targeting ESX-1 mediated pathogenesis of Mycobacterium tuberculosis

Stewart Cole, Florence Pojer, Benjamin Blasco, Jeffrey Chen

Mycobacterium tuberculosis (M. tb) the causative agent of tuberculosis (TB) causes 1.7 million deaths annually. According to the World Health Organization, in some areas of the world, 25% of TB cases are due to multi- or extensively drug resistant M. tb st ...

Elsevier2010