Publications by Bernard Lanz | EPFL Graph Search

Fast High-Resolution Metabolite Mapping in the rat Brain Using 1H-FID-MRSI at 14.1 T

Cristina Ramona Cudalbu, Bernard Lanz, Thanh Phong Kevin Lê, Jessie Julie Mosso, Dunja Simicic

Magnetic resonance spectroscopic imaging (MRSI) enables the simultaneous noninvasive acquisition of MR spectra from multiple spatial locations inside the brain. Although 1H-MRSI is increasingly used in the human brain, it is not yet widely applied in the p ...

2025

Tracking Hyperpolarized [1-¹³C] Pyruvate and [1-¹³C] L-Lactate Metabolism in the Healthy and Post-Stroke Mouse Brain

Rolf Gruetter, Bernard Lanz, Mor-Miri Mishkovsky, Jean-Noël Hyacinthe, Mario Gaetano Lepore, Thanh Phong Kevin Lê, Lara Buscemi Estefanell, Elise Marie Catherine Vinckenbosch

Tracking hyperpolarized (HP) ¹³C labeling from either [1-¹³C] pyruvate or [1-¹³C] lactate is a useful tool to assess intermediary metabolism in vivo, which has already been translated from preclinical to clinical research. HP [1-¹³C] pyruvate and [1-¹³C] l ...

Wiley2025

Ex vivo brain MRI to assess conventional and FLASH brain irradiation effects

Bernard Lanz, Jessie Julie Mosso

Background and purpose: The FLASH effect expands the therapeutic ratio of tumor control to normal tissue toxicity observed after delivery of ultra-high (>100 Gy/s FLASH-RT) vs. conventional dose rate radiation (CONV-RT). In this first exploratory study, we ...

2025

Noise-reduction techniques for 1H-FID-MRSI at 14.1 T: Monte Carlo validation and in vivo application

Cristina Ramona Cudalbu, Bernard Lanz, Thanh Phong Kevin Lê, Jessie Julie Mosso, Dunja Simicic

Proton magnetic resonance spectroscopic imaging (1H-MRSI) is a powerful tool that enables the multidimensional non-invasive mapping of the neurochemical profile at high resolution over the entire brain. The constant demand for higher spatial resolution in ...

Wiley2024

Improved reproducibility of γ-aminobutyric acid measurement from short-echo-time proton MR spectroscopy by linewidth-matched basis sets in LCModel

Lijing Xin, Bernard Lanz, Songi Lim

gamma-Aminobutyric acid (GABA), as the primary inhibitory neurotransmitter, is extremely important for maintaining healthy brain function, and deviations from GABA homeostasis are related to various brain diseases. Short-echo-time (short-TE) proton MR spec ...

Wiley2023

Diffusion-weighted SPECIAL improves the detection of J-coupled metabolites at ultrahigh magnetic field

Rolf Gruetter, Cristina Ramona Cudalbu, Bernard Lanz, Jessie Julie Mosso, Dunja Simicic

PurposeTo improve the detection and subsequent estimation of the diffusion properties of strongly J-coupled metabolites in diffusion-weighted MRS (DWS).MethodsA new sequence for single-voxel diffusion-weighted 1H MR spectroscopy, named DW-SPECIAL, is propo ...

WILEY2023

New Insights Into Brain Energy Metabolism in Type C Hepatic Encephalopathy: A Dual 18F-FDG PET and 9.4T 1H MRS Preclinical Study

Cristina Ramona Cudalbu, Bernard Lanz, Mario Gaetano Lepore, Jessie Julie Mosso, Carole Poitry-Yamate, Dunja Simicic, Ting Yin

Lippincott Williams & Wilkins2023

Deletion of Crtc1 leads to hippocampal neuroenergetic impairments associated with depressive-like behavior

Rolf Gruetter, Maria del Carmen Sandi Perez, Bernard Lanz, Jocelin Grosse, Olivia Zanoletti, Carole Poitry-Yamate, Antoine Timothée Cherix

Mood disorders (MD) are a major burden on society as their biology remains poorly understood, challenging both diagnosis and therapy. Among many observed biological dysfunctions, homeostatic dysregulation, such as metabolic syndrome (MeS), shows considerab ...

SPRINGERNATURE2022

Quantitative FDG-PET and 1H-MRS reveal altered glucose uptake and neurometabolic profiles in BDL rats

Cristina Ramona Cudalbu, Bernard Lanz, Mario Gaetano Lepore, Jessie Julie Mosso, Carole Poitry-Yamate, Dunja Simicic, Ting Yin

SAGE PUBLICATIONS INC2022

PET CMRglc mapping and H-1-MRS show altered glucose uptake and neurometabolic profiles in BDL rats

Cristina Ramona Cudalbu, Bernard Lanz, Mario Gaetano Lepore, Jessie Julie Mosso, Carole Poitry-Yamate, Dunja Simicic, Ting Yin

Type C hepatic encephalopathy (HE) is a complex neuropsychiatric disorder occurring as a consequence of chronic liver disease. Alterations in energy metabolism have been suggested in type C HE, but in vivo studies on this matter remain sparse and have repo ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2022