Luc Reymond

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Targeting protein-ligand neosurfaces with a generalizable deep learning tool

Sebastian Maerkl, Bruno Emanuel Ferreira De Sousa Correia, Luc Reymond, Sandrine Madeleine Suzanne Georgeon, Philippe Schwaller, Anthony Marchand, Leo Scheller, Arne Schneuing, Stephen Michael Buckley, Martin Pacesa

Molecular recognition events between proteins drive biological processes in living systems1. However, higher levels of mechanistic regulation have emerged, in which protein-protein interactions are conditioned to small molecules2, 3, 4-5. Despite recent ad ...

NATURE PORTFOLIO2025

A Silicon Rhodamine-fused Glibenclamide to Label and Detect Malaria-infected Red Blood Cells

Kai Johnsson, Luc Reymond, Johannes Broichhagen

The malaria parasite Plasmodium falciparum affects the lives of millions of people worldwide every year. The detection of replicating parasites within human red blood cells is of paramount importance, requiring appropriate diagnostic tools. Herein, we desi ...

WILEY-V C H VERLAG GMBH2025

Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins

Bruno Emanuel Ferreira De Sousa Correia, Luc Reymond, Florence Pojer, Elisa Oricchio, Sandrine Madeleine Suzanne Georgeon, Albert Santamaria Martinez, Kelvin Ka Ching Lau, Natalya Katanayeva, Aaron Simone Petruzzella, Sarah Wehrle

Cysteine cathepsins are a family of proteases that are relevant therapeutic targets for the treatment of different cancers and other diseases. However, no clinically approved drugs for these proteins exist, as their systemic inhibition can induce deleterio ...

Nature Portfolio2024

Gentle Rhodamines for Live-Cell Fluorescence Microscopy

Luc Reymond

Rhodamines have been continuously optimized in brightness, biocompatibility, and color to fulfill the demands of modern bioimaging. However, the problem of phototoxicity caused by the excited fluorophore under long-term illumination has been largely neglec ...

2024

Fluorescent fatty acid conjugates for live cell imaging of peroxisomes

Luc Reymond, Fabien Kuttler, Milena Maria Schuhmacher, Manon Sandra Bardyn, Daria Korotkova, Triana Amen

Peroxisomes are eukaryotic organelles that are essential for multiple metabolic pathways, including fatty acid oxidation, degradation of amino acids, and biosynthesis of ether lipids. Consequently, peroxisome dysfunction leads to pediatric-onset neurodegen ...

Nature Research2024

Chemical Probe for Imaging of Polo-like Kinase 4 and Centrioles

Kai Johnsson, Pierre Gönczy, Luc Reymond, Georgios Hatzopoulos, Aleksandar Salim

Polo-like kinase (Plk4) is a serine/threonine-proteinkinase thatis essential for biogenesis of the centriole organelle and is enrichedat centrioles. Herein, we introduce Cen-TCO, a chemical probe basedon the Plk4 inhibitor centrinone, to image Plk4 and cen ...

AMER CHEMICAL SOC2023

Tubulin engineering by semi-synthesis reveals that polyglutamylation directs detyrosination

Pierre Gönczy, Beat Fierz, Luc Reymond, Georgios Hatzopoulos, Cédric Pourroy, Po-Han Chang, Nora Guidotti, Ninad Dilip Agashe, Timothy Matthias Reichart, Eduard Hubert Theodoor Marius Ebberink

Microtubules, a critical component of the cytoskeleton, carry post-translational modifications (PTMs) that are important for the regulation of key cellular processes. Long-lived microtubules, in neurons particularly, exhibit both detyrosination of a-tubuli ...

NATURE PORTFOLIO2023

A covalently linked probe to monitor local membrane properties surrounding plasma membrane proteins

Rudolf Hovius, Luc Reymond

We present a method probing the local membrane environment surrounding membrane proteins in the plasma membrane by linking a solvatochromic dye to the target, and provide evidence for lipid-based sorting. The insulin receptor environment changed upon insul ...

Rockefeller University Press2022

Phage Display Selected Cyclic Peptide Inhibitors of Kallikrein-Related Peptidases 5 and 7 and Their In Vivo Delivery to the Skin

Christian Heinis, Luc Reymond, Alessandro Zorzi, Patrick Andreas Gonschorek, Mischa Schüttel, Vanessa Carle, Tamara Maric

Kallikrein-related peptidases 5 (KLK5) and 7 (KLK7) are serine proteases with homeostatic functions in the epidermis that play a critical role in Netherton syndrome (NS), a rare yet life-threatening genetic disorder that currently lacks specific treatment. ...

AMER CHEMICAL SOC2022

Fluorescent D-Amino Acids for Super-resolution Microscopy of the Bacterial Cell Wall

Suliana Manley, Luc Reymond, Ophélie Rutschmann, Willi Leopold Stepp, Juliette Griffie, Chen Zhang, Jiangtao Qiao, Faustine Ambroisine Charline Ryckebusch

Fluorescent D-amino acids (FDAAs) have previ-ously been developed to enable in situ highlighting of locations of bacterial cell wall growth. Most bacterial cells lie at the edge of the diffraction limit of visible light; thus, resolving the precise details ...

2022

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Phage Display Selected Cyclic Peptide Inhibitors of Kallikrein-Related Peptidases 5 and 7 and Their In Vivo Delivery to the Skin

Christian Heinis, Luc Reymond, Alessandro Zorzi, Patrick Andreas Gonschorek, Mischa Schüttel, Vanessa Carle, Tamara Maric

AMER CHEMICAL SOC2022