Sylvain Roy

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In Vivo Testing of a Novel Adjustable Glaucoma Drainage Device

Nikolaos Stergiopoulos, André Mermoud, Sylvain Roy, Adan Villamarin, Stéphane Bigler

PURPOSE. We report on the in vivo testing of a novel noninvasively adjustable glaucoma drainage device (AGDD), which features an adjustable outflow resistance, and assess the safety and efficiency of this implant. METHODS. Under general anesthesia, the AGD ...

Association for Research in Vision and Ophthalmology2014

3D simulation of the aqueous flow in the human eye

Nikolaos Stergiopoulos, Sylvain Roy, Adan Villamarin, Philippe Reymond, Orestis Vardoulis, Reda Hasballa

Glaucoma results in an increase in the resistance of the aqueous humor outflow, which in turn leads to an increase of the intraocular pressure (IOP). Several treatments are proposed to reduce and stabilize the IOP that include medications, filtering surger ...

Elsevier Sci Ltd2012

Experimental characterization of the distribution of collagen fiber recruitment

Nikolaos Stergiopoulos, Sylvain Roy, Christophe Boss

The passive biomechanical behavior of blood vessels is generally modeled by a parallel arrangement of elastin and collagen, with collagen recruitment depending on vessel strain. We experimentally determined the collagen recruitment distribution using confo ...

2010

Deep sclerectomy with the Ex-PRESS X-200 implant for the surgical treatment of glaucoma

André Mermoud, Sylvain Roy

Springer, Springer Netherlands2010

Arterial biomechanics after destruction of cytoskeleton by Cytochalasin D

Nikolaos Stergiopoulos, Sylvain Roy, Paolo Silacci, Tyler Nerton Thacher

Vascular smooth muscle is a major structural element of the arterial wall. We examined the effects of cytoskeleton destruction, after administration of Cytochalasin D, on the biomechanical properties of porcine common carotids. Compared to untreated, maxim ...

2009

Biocompatibility of an x-shaped zirconium implant in deep sclerectomy in rabbits

André Mermoud, Sylvain Roy

Springer, Springer-Verlag2008

Vascular physiology : effects of vascular smooth muscle alteration on arterial wall biomechanics

Sylvain Roy

This thesis aims at better understanding the role played by vascular smooth muscle cells (VSM) in the biomechanics of the arterial wall. Current models assume that under maximal vasodilation VSM carry no load, or the so-called "active stress" is zero. Biom ...

EPFL2008

Endothelialization Of Decellularized Porcine Arteries

Nikolaos Stergiopoulos, Sylvain Roy, Paolo Silacci

2008

On the in-series and in-parallel contribution of elastin assessed by a structure-based biomechanical model of the arterial wall

Nikolaos Stergiopoulos, Sylvain Roy, Alkiviadis Tsamis, Gilles Prod'Hom

Earlier experimental work on decellularized arteries revealed the existence of significant residual stresses within the arterial wall, which are released upon chemical removal of vascular smooth muscle in normal arteries causing substantial radial expansio ...

2008

Effect of elastin degradation on carotid wall mechanics as assessed by a constituent-based biomechanical model

Nikolaos Stergiopoulos, Sylvain Roy, Luca Augsburger, Edouard Fonck, Gilles Prod'Hom

Arteries display a nonlinear anisotropic behavior dictated by the elastic properties and structural arrangement of its main constituents, elastin, collagen, and vascular smooth muscle. Elastin provides for structural integrity and for the compliance of the ...

2007

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On the in-series and in-parallel contribution of elastin assessed by a structure-based biomechanical model of the arterial wall

Nikolaos Stergiopoulos, Sylvain Roy, Alkiviadis Tsamis, Gilles Prod'Hom

2008

Effect of elastin degradation on carotid wall mechanics as assessed by a constituent-based biomechanical model

Nikolaos Stergiopoulos, Sylvain Roy, Luca Augsburger, Edouard Fonck, Gilles Prod'Hom

2007

Endothelialization Of Decellularized Porcine Arteries

Nikolaos Stergiopoulos, Sylvain Roy, Paolo Silacci

2008