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Patrick Segers
Related publications (40)
Dissecting Abdominal Aortic Aneurysm in Angiotensin II-Infused Mice: The Importance of Imaging
Nikolaos Stergiopoulos, Bram Trachet, Alessandra Piersigilli, Patrick Segers
Introduction. Since the initial publication in 2000, Angiotensin II-infused mice have become one of the most popular models to study abdominal aortic aneurysm in a pre-clinical setting. We recently used phase contrast X-ray based computed tomography to dem ...
2015Vulnerable Plaque Detection and Quantification with Gold Particle-Enhanced Computed Tomography in Atherosclerotic Mouse Models
Recently, an apolipoprotein E-deficient (ApoE(-/-)) mouse model with a mutation (C1039G+/-) in the fibrillin-1 (Fbn1) gene (ApoE(-/-)Fbn1(C1039G+/-) mouse model) was developed showing vulnerable atherosclerotic plaques, prone to rupture, in contrast to the ...
B C Decker Inc2015Ambulatory arterial stiffness index does not accurately assess arterial stiffness
Nikolaos Stergiopoulos, Philippe Reymond, Patrick Segers
Introduction: The ambulatory arterial stiffness index (AASI), derived from ambulatory blood pressure monitoring (ABPM) recordings, has been proposed as a surrogate marker of arterial stiffness. However, there is controversy to what extent it reflects stiff ...
Lippincott, Williams & Wilkins2012Numerical validation of a new method to assess aortic pulse wave velocity from a single recording of a brachial artery waveform with an occluding cuff
Nikolaos Stergiopoulos, Philippe Reymond, Bram Trachet, Patrick Segers
Recently a new method has been proposed as a tool to measure arterial pulse wave velocity (PWV), a measure of the stiffness of the large arteries and an emerging parameter used as indicator of clinical cardiovascular risk. The method is based on measuremen ...
Springer Verlag2010Three- and four-element Windkessel models: assessment of their fitting performance in a large cohort of healthy middle-aged individuals
Nikolaos Stergiopoulos, Patrick Segers, Nico Westerhof
Lumped-parameter models are used to estimate the global arterial properties by fitting the model to measured (aortic) pressure and flow. Different model configurations coexist, and it is still an open question as to which model optimally reflects the arter ...
2008Effect of an abdominal aortic aneurysm on wave reflection in the aorta
Nikolaos Stergiopoulos, Patrick Segers
Despite extensive attention to abdominal aortic aneurysm (AAA) in the biomedical engineering community, its effect on aortic hemodynamics and arterial wave reflection has not been addressed before. We used experimental and numerical methods, relying on a r ...
2008Effects of an aging vascular model on healthy and diseased hearts
Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, David Jegger, Patrick Segers
The vitamin D(3) and nicotine (VDN) model is a model of isolated systolic hypertension (ISH) due to arterial calcification raising arterial stiffness and vascular impedance similar to an aged and stiffened arterial tree. We therefore analyzed the impact of ...
2007Noninvasive Doppler-derived myocardial performance index in rats with myocardial infarction: validation and correlation by conductance catheter
Nikolaos Stergiopoulos, David Jegger, Patrick Segers
The rodent model of myocardial infarction (MI) is extensively used in heart failure studies. However, long-term follow-up of echocardiographic left ventricular (LV) function parameters such as the myocardial performance index (MPI) and its ratio with the f ...
2005Nonlinear isochrones in murine left ventricular pressure-volume loops: how well does the time-varying elastance concept hold?
Nikolaos Stergiopoulos, Patrick Segers, Nico Westerhof
The linear time-varying elastance theory is frequently used to describe the change in ventricular stiffness during the cardiac cycle. The concept assumes that all isochrones (i.e., curves that connect pressure-volume data occurring at the same time) are li ...
2005Conductance catheter-based assessment of arterial input impedance, arterial function, and ventricular-vascular interaction in mice
Nikolaos Stergiopoulos, Patrick Segers, Nico Westerhof
Global assessment of both cardiac and arterial function is important for a meaningful interpretation of pathophysiological changes in animal models of cardiovascular disease. We simultaneously acquired left ventricular (LV) and aortic pressure and LV volum ...
2004