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Heike Runne

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Heike Runne

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SIRT2-and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models

Synchrotron Infrared Microspectroscopy Detecting the Evolution of Huntington's Disease Neuropathology and Suggesting Unique Correlates of Dysfunction in White versus Gray Brain Matter

Developmental expression of Synaptotagmin isoforms in single calyx of Held-generating neurons

Diminished activity-dependent brain-derived neurotrophic factor expression underlies cortical neuron microcircuit hypoconnectivity resulting from exposure to mutant huntingtin fragments

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

Short-term striatal gene expression responses to brain-derived neurotrophic factor are dependent on MEK and ERK activation

Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry

Transcriptional dysregulation in Huntington's disease

Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood