Publications by Sylvain Crochet

Experimental and computational analysis of REM sleep distributed cortical activity in mice

Although classically Rapid-Eye Movement (REM) sleep was thought to generate desynchronized activity similar to wakefulness, it was found that some brain regions could express Slow Wave activity (SWA), a pattern which was normally typical of slow-wave sleep ...

American Physiological Society2025

Cell-class-specific orofacial motor maps in mouse neocortex

Carl Petersen, Sylvain Crochet, Pol Bech Vilaseca, Keita Tamura

Cortical motor maps represent fundamental organizing principles for voluntary motor control,1 yet their underlying structure remains poorly understood, including regions of sensory2,3 and parietal cortex,4 as well as the classical frontal motor cortex. To ...

2025

Dopamine dynamics in nucleus accumbens across reward-based learning of goal-directed whisker-to-lick sensorimotor transformations in mice

Maria del Carmen Sandi Perez, Carl Petersen, Sylvain Crochet, Jun Huang

The synaptic and neuronal circuit mechanisms underlying reward-based learning remain to be fully determined. In the mammalian brain, dopamine release in nucleus accumbens is thought to contribute importantly to reward signals for learning and promoting syn ...

Elsevier BV2024

Cell class-specific long-range axonal projections of neurons in mouse whisker-related somatosensory cortices

Carl Petersen, Sylvain Crochet, Pol Bech Vilaseca, Yanqi Liu, Keita Tamura

Long-range axonal projections of diverse classes of neocortical excitatory neurons likely contribute to brain-wide interactions processing sensory, cognitive and motor signals. Here, we performed light-sheet imaging of fluorescently labeled axons from gene ...

2024

Membrane potential dynamics of excitatory and inhibitory neurons in mouse barrel cortex during active whisker sensing

Carl Petersen, Sylvain Crochet, Aurélie Pala, Taro Kiritani, Célia Roxane Gasselin

Neocortical neurons can increasingly be divided into well-defined classes, but their activity patterns during quantified behavior remain to be fully determined. Here, we obtained membrane potential recordings from various classes of excitatory and inhibito ...

PUBLIC LIBRARY SCIENCE2023

Striatal Dopamine Signals and Reward Learning

Carl Petersen, Sylvain Crochet, Parviz Ghaderi, Mauro Pulin, Anthony Pierre Robert Renard, Christos Sourmpis, Pol Bech Vilaseca, Meriam Malekzadeh, Robin François Virginien Dard, Yanqi Liu

We are constantly bombarded by sensory information and constantly making decisions on how to act. In order to optimally adapt behavior, we must judge which sequences of sensory inputs and actions lead to successful outcomes in specific circumstances. Neuro ...

Oxford Univ Press2023

Distributed and specific encoding of sensory, motor, and decision information in the mouse neocortex during goal-directed behavior

Wulfram Gerstner, Carl Petersen, Sylvain Crochet, Alireza Modirshanechi, Vahid Esmaeili, Christos Sourmpis, Anastasiia Oryshchuk

Goal-directed behaviors involve coordinated activity in many cortical areas, but whether the encoding of task variables is distributed across areas or is more specifically represented in distinct areas remains unclear. Here, we compared representations of ...

Cell Press2023

Axonal and Dendritic Morphology of Excitatory Neurons in Layer 2/3 Mouse Barrel Cortex Imaged Through Whole-Brain Two-Photon Tomography and Registered to a Digital Brain Atlas

Carl Petersen, Sylvain Crochet, Georgios Foustoukos, Yanqi Liu

Communication between cortical areas contributes importantly to sensory perception and cognition. On the millisecond time scale, information is signaled from one brain area to another by action potentials propagating across long-range axonal arborizations. ...

FRONTIERS MEDIA SA2022

Learning-related congruent and incongruent changes of excitation and inhibition in distinct cortical areas

Carl Petersen, Sylvain Crochet, Romain Guiet, Vahid Esmaeili, Georgios Foustoukos, Yanqi Liu, Keita Tamura, Anastasiia Oryshchuk, Reza Asri

Excitatory and inhibitory neurons in diverse cortical regions are likely to contribute differentially to the transformation of sensory information into goal-directed motor plans. Here, we investigate the relative changes across mouse sensorimotor cortex in ...

2022

Cell Type-Specific Membrane Potential Changes in Dorsolateral Striatum Accompanying Reward-Based Sensorimotor Learning

Carl Petersen, Sylvain Crochet, Tanya C Sippy

The striatum integrates sensorimotor and motivational signals, likely playing a key role in reward-based learning of goal-directed behavior. However, cell type-specific mechanisms underlying reinforcement learning remain to be precisely determined. Here, w ...

OXFORD UNIV PRESS2021