Publications by Ziad Julier | EPFL Graph Search

FOLDING OF COMPLEX REDOX PROTEINS BY DEDICATED MOLECULAR CHAPERONES

Julien Maillard, Ziad Julier, Corantin Grob

Chlorinated compounds (so-called organohalides) are widespread soil and groundwater pollutants. Only few bacteria have the ability to degrade these compounds via organohalide respiration (OHR). Reductive dehalogenases (RDases) are complex redox enzymes inv ...

2016

Fibronectin EDA and CpG synergize to enhance antigen-specific Th1 and cytotoxic responses

Eleonora Simeoni, Jeffrey Alan Hubbell, Melody Swartz, Alexandre de Titta, Alizée Jéléna Grimm, Ziad Julier

Subunit vaccines, employing purified protein antigens rather than intact pathogens, require the addition of adjuvants for enhanced immunogenicity with a correct balance between strong activation of the immune system and low toxicity. Here we show that the ...

Elsevier Sci Ltd2016

The TLR4 Agonist Fibronectin Extra Domain A is Cryptic, Exposed by Elastase-2; use in a fibrin matrix cancer vaccine

Jeffrey Alan Hubbell, Mikaël Martino, Alexandre de Titta, Laura Jeanbart, Ziad Julier

Fibronectin (FN) is an extracellular matrix (ECM) protein including numerous fibronectin type III (FNIII) repeats with different functions. The alternatively spliced FN variant containing the extra domain A (FNIII EDA), located between FNIII 11 and FNIII 1 ...

Nature Publishing Group2015

Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose

Jeffrey Alan Hubbell, Melody Swartz, Alexandre de Titta, Marie Ballester, Laura Jeanbart, Ziad Julier

In subunit vaccines, strong CD8(+) T-cell responses are desired, yet they are elusive at reasonable adjuvant doses. We show that targeting adjuvant to the lymph node (LN) via ultrasmall polymeric nanoparticles (NPs), which rapidly drain to the LN after int ...

Natl Acad Sciences2013

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Ziad Julier

Engineering the Extra Domain A of fibronectin as a vaccine adjuvant and study of its role in tissue regeneration

FOLDING OF COMPLEX REDOX PROTEINS BY DEDICATED MOLECULAR CHAPERONES

Fibronectin EDA and CpG synergize to enhance antigen-specific Th1 and cytotoxic responses

The TLR4 Agonist Fibronectin Extra Domain A is Cryptic, Exposed by Elastase-2; use in a fibrin matrix cancer vaccine

Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose

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Engineering the Extra Domain A of fibronectin as a vaccine adjuvant and study of its role in tissue regeneration

Fibronectin EDA and CpG synergize to enhance antigen-specific Th1 and cytotoxic responses

The TLR4 Agonist Fibronectin Extra Domain A is Cryptic, Exposed by Elastase-2; use in a fibrin matrix cancer vaccine

Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose