Marc Moniatte

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Alpha-synuclein Post-translational Modifications as Potential Biomarkers for Parkinson Disease and Other Synucleinopathies

Hilal Lashuel, Bruno Claude Daniel Fauvet, Marc Moniatte, Adrian Schmid

The development of novel therapies against neurodegenerative disorders requires the ability to detect their early, presymptomatic manifestations in order to enable treatment before irreversible cellular damage occurs. Precocious signs indicative of neurode ...

Amer Soc Biochemistry Molecular Biology Inc2013

A quantitative telomeric chromatin isolation protocol identifies different telomeric states

Joachim Lingner, Romain Hamelin, Eric Aeby, Larissa Grolimund, Florence Armand, Diego Chiappe, Marc Moniatte

Telomere composition changes during tumourigenesis, aging and in telomere syndromes in a poorly defined manner. Here we develop a quantitative telomeric chromatin isolation protocol (QTIP) for human cells, in which chromatin is cross-linked, immunopurified ...

Nature Publishing Group2013

Surface charge of polymer coated SPIONs influences the serum protein adsorption, colloidal stability and subsequent cell interaction in vitro

Alke Fink, Marc Moniatte

It is known that the nanoparticle-cell interaction strongly depends on the physicochemical properties of the investigated particles. In addition, medium density and viscosity influence the colloidal behaviour of nanoparticles. Here, we show how nanoparticl ...

Royal Soc Chemistry2013

Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathway

Guillem Dayer, Romain Hamelin, Marc Moniatte, Amit Sharma

Background: Protein kinase CK2 is a pleiotropic serine/threonine protein kinase with hundreds of reported substrates, and plays an important role in a number of cellular processes. The cellular functions of Plasmodium falciparum CK2 (PfCK2) are unknown. Th ...

2012

Tissue Transglutaminase-mediated Glutamine Deamidation of beta-Amyloid Peptide Increases Peptide Solubility, Whereas Enzymatic Cross-linking and Peptide Fragmentation May Serve as Molecular Triggers for Rapid Peptide Aggregation

Horst Vogel, Yury Tsybin, Enrico Condemi, Diego Chiappe, Marc Moniatte, Adrian Schmid

Tissue transglutaminase (TGase) has been implicated in a number of cellular processes and disease states, where the enzymatic actions of TGase may serve in both, cell survival and apoptosis. To date, the precise functional properties of TGase in cell survi ...

American Society for Biochemistry and Molecular Biology2011

Activation of a PAK-MEK signalling pathway in malaria parasite-infected erythrocytes

Romain Hamelin, Marc Moniatte

P>Merozoites of malaria parasites invade red blood cells (RBCs), where they multiply by schizogony, undergoing development through ring, trophozoite and schizont stages that are responsible for malaria pathogenesis. Here, we report that a protein kinase-me ...

Wiley-Blackwell2011

Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions

Hilal Lashuel, Patrick Aebischer, Bernard Schneider, Adrian Schmid, Diego Chiappe, Abid Oueslati, Marc Moniatte, Magdalena Zweckstetter

Increasing evidence suggests that phosphorylation may play an important role in the oligomerization, fibrillogenesis, Lewy body (LB) formation, and neurotoxicity of alpha-synuclein (alpha-syn) in Parkinson disease. Herein we demonstrate that alpha-syn is p ...

2010

Validation of a nanoliquid chromatography-tandem mass spectrometry method for the identification and the accurate quantification by isotopic dilution of glutathionylated and cysteinylated precursors of 3-mercaptohexan-1-ol and 4-mercapto-4-methylpentan-2-one in white grape juices

Marc Moniatte, Jérôme Vialaret

A rapid nanoLc-MS/MS method was developed and validated for the simultaneous determination of glutathionylated and cysteinylated precursors of 3-mercapto-hexan-1-ol (3MH) and 4-methyl-4-mercaptopentan-2-one in grape juice using stable isotope dilution assa ...

2010

Electron Capture and Transfer Dissociation: Peptide Structure Analysis at Different Ion Internal Energy Levels

Yury Tsybin, Hisham Ben Hamidane, Diego Chiappe, Marc Moniatte, Aleksey Vorobyev

We decoupled electron-transfer dissociation (ETD) and collision-induced dissociation of charge-reduced species (CRCID) events to probe the lifetimes of intermediate radical species in ETD-based ion trap tandem mass spectrometry of peptides. Short-lived int ...

Springer-Verlag2009

Superparamagnetic Nanoparticles as a Powerful Systems Biology. Characterization Tool in the Physiological Context

Heinrich Hofmann, Jeffrey Alan Hubbell, Alke Fink, Benedikt Steitz, Marc Moniatte, Conlin O'Neil, Andrija Finka, Jatuporn Salaklang

Recently, functionalized superparamagnetic iron oxide nanoparticles (SPIONs) have been utilized for protein separation and therapeutic delivery of DNA and drugs. The development of new methods and tools for the targeting and identification of specific biom ...

Wiley-Blackwell2008

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