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Felix Schürmann

This person is no longer with EPFL

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Modernizing the NEURON Simulator for Sustainability, Portability, and Performance

James Gonzalo King, Felix Schürmann, Pramod Shivaji Kumbhar, Omar Awile, Ioannis Magkanaris

The need for reproducible, credible, multiscale biological modeling has led to the development of standardized simulation platforms, such as the widely-used NEURON environment for computational neuroscience. Developing and maintaining NEURON over several d ...

2022

Computational Concepts for Reconstructing and Simulating Brain Tissue

Srikanth Ramaswamy, Felix Schürmann, Jean-Denis Georges Emile Courcol

It has previously been shown that it is possible to derive a new class of biophysically detailed brain tissue models when one computationally analyzes and exploits the interdependencies or the multi-modal and multi-scale organization of the brain. These re ...

Springer2022

STEPS 4.0: Fast and memory-efficient molecular simulations of neurons at the nanoscale

Felix Schürmann, James Gonzalo King, Pramod Shivaji Kumbhar, Omar Awile, Christos Kotsalos, Tristan Mathieu Carel, Iain Hepburn, Samuel Marie A Melchior, Weiliang Chen, Baudouin Paul Michel Maria Joseph Del Marmol

Recent advances in computational neuroscience have demonstrated the usefulness and importance of stochastic, spatial reaction-diffusion simulations. However, ever increasing model complexity renders traditional serial solvers, as well as naive parallel imp ...

FRONTIERS MEDIA SA2022

EBRAINS Live Papers-Interactive Resource Sheets for Computational Studies in Neuroscience

Felix Schürmann

We present here an online platform for sharing resources underlying publications in neuroscience. It enables authors to easily upload and distribute digital resources, such as data, code, and notebooks, in a structured and systematic way. Interactivity is ...

HUMANA PRESS INC2022

Representing stimulus information in an energy metabolism pathway

Henry Markram, Felix Schürmann, Daniel Keller, Jay Coggan

We explored a computational model of astrocytic energy metabolism and demonstrated the theoretical plausibility that this type of pathway might be capable of coding information about stimuli in addition to its known functions in cellular energy and carbon ...

2022

Reconstruction of the Hippocampus

Henry Markram, Armando Romani, Felix Schürmann, Michele Migliore

The hippocampus is a widely studied brain region thought to play an important role in higher cognitive functions such as learning, memory, and navigation. The amount of data on this region increases every day and delineates a complex and fragmented picture ...

Springer2022

Meshing of Spiny Neuronal Morphologies using Union Operators

Felix Schürmann, Marwan Muhammad Ahmed Abdellah, Elvis Boci, Nadir Roman Guerrero, Juan José García Cantero, Alessandro Enrico Foni

Neurons are characterized by thin and long interleaving arborizations in which creating accurate mesh models of their cellular membranes is challenging. While union operators are central for CAD/CAM modeling and computer graphics applications, their applic ...

2022

Metaball skinning of synthetic astroglial morphologies into realistic mesh models for visual analytics and in silico simulations

Henry Markram, Felix Schürmann, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Jay Coggan, Samuel Lieven D. Lapere, Nadir Roman Guerrero, Alessandro Enrico Foni, Eleftherios Zisis

Motivation: Astrocytes, the most abundant glial cells in the mammalian brain, have an instrumental role in developing neuronal circuits. They contribute to the physical structuring of the brain, modulating synaptic activity and maintaining the blood-brain ...

OXFORD UNIV PRESS2021

ARC: An Open Web-Platform for Request/Supply Matching for a Prioritized and Controlled COVID-19 Response

Henry Markram, Felix Schürmann, Jean-Denis Georges Emile Courcol

In 2020 the world was hit by the COVID-19 pandemic putting entire governments and civil societies in crisis mode. Around the globe unprecedented shortages of equipment and qualified personnel were reported in hospitals and diagnostic laboratories. When a c ...

FRONTIERS MEDIA SA2021

The Role of Hub Neurons in Modulating Cortical Dynamics

Henry Markram, Felix Schürmann, Idan Segev, Oren Amsalem, Eyal Gal, Michael London

Many neurodegenerative diseases are associated with the death of specific neuron types in particular brain regions. What makes the death of specific neuron types particularly harmful for the integrity and dynamics of the respective network is not well unde ...

2021

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Metaball skinning of synthetic astroglial morphologies into realistic mesh models for visual analytics and in silico simulations

Henry Markram, Felix Schürmann, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Jay Coggan, Samuel Lieven D. Lapere, Nadir Roman Guerrero, Alessandro Enrico Foni, Eleftherios Zisis

OXFORD UNIV PRESS2021

ARC: An Open Web-Platform for Request/Supply Matching for a Prioritized and Controlled COVID-19 Response

Henry Markram, Felix Schürmann, Jean-Denis Georges Emile Courcol

FRONTIERS MEDIA SA2021

The Role of Hub Neurons in Modulating Cortical Dynamics

Henry Markram, Felix Schürmann, Idan Segev, Oren Amsalem, Eyal Gal, Michael London

2021