Person

Françoise Gisou van der Goot Grunberg

Related publications (153)

Endocytosis of the anthrax toxin is mediated by clathrin, actin and unconventional adaptors

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Béatrice Kunz, Mirko Bischofberger, Romain Fernand Pietro Groux

The anthrax toxin is a tripartite toxin, where the two enzymatic subunits require the third subunit, the protective antigen (PA), to interact with cells and be escorted to their cytoplasmic targets. PA binds to cells via one of two receptors, TEM8 and CMG2 ...

Public Library of Science2010

Novel ubiquitin-dependent quality control in the endoplasmic reticulum

Françoise Gisou van der Goot Grunberg, Michal Feldman Elmalam

Proteins of the endomembrane system undergo assisted folding in the endoplasmic reticulum (ER), then quality-control and, if misfolded, ER-associated degradation (ERAD). Recent findings on the biogenesis of a type-I membrane protein (an LRP6 mutant) lead u ...

Elsevier2009

Systemic hyalinosis mutations in the CMG2 ectodomain leading to loss of function through retention in the endoplasmic reticulum

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Julie Deuquet Ariosa

Systemic hyalinosis is an autosomal recessive disease that encompasses two allelic syndromes, infantile systemic hyalinosis (ISH) and juvenile hyaline fibromatosis (JHF), which are caused by mutations in the CMG2 gene. Here we have analyzed the cellular co ...

Wiley-Blackwell2009

Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy

Françoise Gisou van der Goot Grunberg, Nicolas Dupont

Intracellular pathogens like Shigella flexneri enter host cells by phagocytosis. Once inside, the pathogen breaks the vacuolar membrane for cytosolic access. The fate and function of the vacuolar membrane remnants are not clear. Examining Shigella-infected ...

2009

Membrane injury by pore-forming proteins

Françoise Gisou van der Goot Grunberg, Mirko Bischofberger, Rodrigo Manuel Gonzalez

The plasma membrane defines the boundary of every living cell, and its integrity is essential for life. The plasma membrane may, however, be challenged by mechanical stress or pore-forming proteins produced by the organism itself or invading pathogens. We ...

Elsevier2009

Receptors of anthrax toxin and cell entry

Françoise Gisou van der Goot Grunberg

Anthrax toxin-receptor interactions are critical for toxin delivery to the host cell cytoplasm. This review summarizes what is known about the molecular details of the protective antigen (PA) toxin subunit interaction with either the ANTXR1 and ANTXR2 cell ...

Elsevier2009

Getting the Opportunity to Fly on your own

Françoise Gisou van der Goot Grunberg

The author describes the beginning of her independent scientific career in the Department of Biochemistry of the University of Geneva, at a time when Assistant Professor positions did not exist there and female group leaders in the Section of Chemistry wer ...

2009

Regulation of the V-ATPase along the endocytic pathway occurs through reversible subunit association and membrane localization

Françoise Gisou van der Goot Grunberg, Céline Lafourcade

The lumen of endosomal organelles becomes increasingly acidic when going from the cell surface to lysosomes. Luminal pH thereby regulates important processes such as the release of internalized ligands from their receptor or the activation of lysosomal enz ...

Public Library of Science2008

Palmitoylation of membrane proteins (Review)

Françoise Gisou van der Goot Grunberg

S-Palmitoylation is a reversible post-translational modification that results in the addition of a C16-carbon saturated fatty acyl chain to cytoplasmic cysteine residues. This modification is mediated by Palmitoyl-acyl Transferases that are starting to be ...

Taylor & Francis2008

Maturation modulates caspase-1-independent responses of dendritic cells to Anthrax lethal toxin

Françoise Gisou van der Goot Grunberg

Anthrax lethal toxin (LT) contributes to the immune evasion strategy of Bacillus anthracis by impairing the function of cells of the immune system, such as macrophages and dendritic cells (DCs). Macrophages from certain inbred mice strains undergo rapid de ...

2008

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