Publications by Davide Demurtas

Assessing the Role of Poly(ethylehe glycol-bl-propylene sulfide) (PEG-PPS) Block Copolymers in the Preparation of Carbon Nanotube Biocompatible Dispersions

Davide Demurtas, Jeffrey Alan Hubbell, Conlin O'Neil

Amphiphilic block copolymers based on hydrophobic polysulfides (poly(propylene sulfide), PPS) and hydrophilic polyethers (poly(ethylene glycol), PEG) have been used to solubilize and disperse single-walled carbon nanotubes (SWNTs). The obtained highly conc ...

2010

Bending modes of DNA directly addressed by cryo-electron microscopy of DNA minicircles

Davide Demurtas, John Maddocks, Andrzej Stasiak, Jacques Dubochet, Arnaud Amzallag

We use cryo-electron microscopy (cryo-EM) to study the 3D shapes of 94-bp-long DNA minicircles and address the question of whether cyclization of such short DNA molecules necessitates the formation of sharp, localized kinks in DNA or whether the necessary ...

Oxford University Press2009

A Novel Method for the Encapsulation of Biomolecules into Polymersomes via Direct Hydration

Davide Demurtas, Jeffrey Alan Hubbell, Conlin O'Neil, Andrija Finka

One of the major engineering challenges for the implementation of block copolymer vesicles, or polymersomes, as therapeutic drug carriers is obtaining high encapsulation efficiencies for biomolecules. Here we present it novel method for encapsulation of pr ...

2009

Extracellular matrix binding mixed micelles for drug delivery applications

Davide Demurtas, Jeffrey Alan Hubbell, Jutta Christine Wandrey

Received 5 January 2009 Accepted 22 March 2009 Available online 27 March 2009 Keywords: Mixed micelles Drug delivery Block copolymers Sirolimus Extracellular matrix We present the formation of collagen-binding mixed micelles and their potential suitability ...

2009

Micelles for delivery of nitric oxide

Nikolaos Stergiopoulos, Davide Demurtas, Jeffrey Alan Hubbell, Simone Cavadini, Tyler Nerton Thacher, Yun Suk Jo, Jay Gantz

We designed block copolymer pro-amphiphiles and amphiphiles for providing very long-term release of nitric oxide (NO). A block copolymer of N-acryloylmorpholine (AM, as a hydrophile) and N-acryloyl-2,5-dimethylpiperazine (AZd, as a hydrophilic precursor) w ...

2009

RAFT homo- and copolymerization of N-acryloyl-morpholine, piperidine, and azocane and their self-assembled structures

Davide Demurtas, Jeffrey Alan Hubbell, Yun Suk Jo, Jay Gantz

We present new polymeric amphiphiles derived from N-acryloyl derivatives of the cyclic secondary amines: morpholine, piperidine, and azocane polymerized by reversible addition -fragmentation transfer (RAFT) polymerization. Both homopolymerization and block ...

2008

PEG-b-PPS diblock copolymer aggregates for hydrophobic drug solubilization and release: Cyclosporin A as an example

Davide Demurtas, Jeffrey Alan Hubbell

Micelles formed from amphiphilic block copolymers have been explored in recent years as carriers for hydrophobic drugs. In an aqueous environment, the hydrophobic blocks form the core of the micelle, which can host lipophilic drugs, while the hydrophilic b ...

2008

Multifunctional Lipid/Quantum-Dots Hybrid Nanocontainers for Controlled Targeting of Live Cells

Horst Vogel, Davide Demurtas, Pierre-Yves Bolinger, Christophe Danelon, Jacques Dubochet, Paulina Izewska, Gopakumar Gopalakrishnan

In this communication, we report on an interesting observation of wide-ranging potential for cellular imaging and manipulation: Hydrophobic QDs can be easily incorporated into the bilayer membrane of lipid vesicles. Such lipid/QD nanocontainer hybrid vesic ...

2006

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