Yury Tsybin

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Gold finger formation studied by high-resolution mass spectrometry and in silico methods

Yury Tsybin, Angela Casini, Unige Anna Laskay

High-resolution mass spectrometry and quantum mechanics/molecular mechanics studies were employed for characterizing the formation of two gold finger (GF) domains from the reaction of zinc fingers (ZF) with gold complexes. The influence of both the gold ox ...

Royal Society of Chemistry2015

Identification of hemoglobin variants by top-down mass spectrometry using selected diagnostic product ions

Yury Tsybin

Hemoglobin disorder diagnosis is a complex procedure combining several analytical steps. Due to the lack of specificity of the currently used protein analysis methods, the identification of uncommon hemoglobin variants (proteoforms) can become a hard task ...

Springer Heidelberg2015

Producing absorption mode Fourier transform ion cyclotron resonance mass spectra with non-quadratic phase correction functions

Yury Tsybin, Anton Kozhinov, Konstantin Nagornov, Konstantin Zhurov

RATIONALE: Previously described methods for producing absorption mode Fourier transform ion cyclotron resonance (FTICR) mass spectra have all relied on the phase correction function being quadratic. This assumption has been found to be invalid for some ins ...

Wiley-Blackwell2015

A Functional Group Approach for Prediction of APPI Response of Organic Synthetic Targets

Yury Tsybin, Konstantin Zhurov, Laure Menin, Thomas Clément Di Franco

Atmospheric pressure photoionization (APPI) is a technique of choice for ionization of non-polar molecules in mass spectrometry (MS). Reported APPI-based studies tend to focus on a selected compound class, which may contain a variety of functional groups. ...

Springer2015

On the use of electron capture rate constants to describe electron capture dissociation mass spectrometry of peptides

Yury Tsybin, Konstantin Zhurov, Aleksey Vorobyev, Unige Anna Laskay

Electron capture dissociation (ECD) tandem mass spectrometry (MS/MS) is a powerful analytical tool for peptide and protein structure analysis. The product ion abundance (PIA) distribution in ECD MS/MS is known to vary as a function of electron irradiation ...

Im Publications2015

Time-dependent frequency of ion motion in Fourier transform mass spectrometry

Yury Tsybin

Recent experimental and theoretical findings suggest that the concept of time-dependent instantaneous frequency(IF) is required to comprehensively describe ion motion and mass spectra generation in Fourier transform mass spectrometry (FTMS). Here, we deriv ...

Elsevier Science Bv2015

Distinguishing analyte from noise components in mass spectra of complex samples: where to cut the noise?

Yury Tsybin, Anton Kozhinov, Luca Fornelli, Konstantin Zhurov

Fourier transform mass spectrometry (FTMS) enables comprehensive analysis of complex molecular mixtures. Given the broad intensity ranges of components in the mass spectra, it is imperative to accurately determine a noise threshold level above which peak a ...

Amer Chemical Soc2014

Ping-Pong Protons: How Hydrogen Bonding Networks Facilitate Heterolytic Bond Cleavages in Peptide Radical Cations

Yury Tsybin, Matthew Wodrich, Anne-Clémence Corminboeuf, Konstantin Zhurov

Electron capture and electron transfer dissociation (ECD/ETD) tandem mass spectrometry (MS/MS) are commonly employed techniques for biomolecular analysis. The ECD/ETD process predominately cleaves N-C-alpha peptide backbone bonds, leading to primary sequen ...

Amer Chemical Soc2014

Extended Bottom-Up Proteomics with Secreted Aspartic Protease Sap9

Yury Tsybin, Kristina Srzentic, Unige Anna Laskay

We investigate the benefits and experimental feasibility of approaches enabling the shift from short (1.7 kDa on average) peptides in bottom-up proteomics to about twice longer (similar to 3.2 kDa on average) peptides in the so-called extended bottom-up pr ...

Elsevier Science Bv2014

On the Viability of Heterolytic Peptide N-Calpha Bond Cleavage in Electron Capture and Transfer Dissociation Mass Spectrometry

Yury Tsybin, Matthew Wodrich, Anne-Clémence Corminboeuf, Konstantin Zhurov

While frequently employed as an experimental technique, the mechanistic picture surrounding the gas-phase dissociation of peptides carrying multiple positive charges during electron capture and electron transfer dissociation tandem mass spectrometry remain ...

Amer Chemical Soc2014

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Producing absorption mode Fourier transform ion cyclotron resonance mass spectra with non-quadratic phase correction functions

Yury Tsybin, Anton Kozhinov, Konstantin Nagornov, Konstantin Zhurov

Wiley-Blackwell2015

On the Viability of Heterolytic Peptide N-Calpha Bond Cleavage in Electron Capture and Transfer Dissociation Mass Spectrometry

Yury Tsybin, Matthew Wodrich, Anne-Clémence Corminboeuf, Konstantin Zhurov

Amer Chemical Soc2014