Publications by Alireza Roshan Ghias

Translation of biomechanical concepts in bone tissue engineering: from animal study to revision knee arthroplasty

Dominique Pioletti, Alexandre Terrier, Brigitte Jolles-Haeberli, Alireza Roshan Ghias

Bone defects in revision knee arthroplasty (RKA) are often located in load-bearing regions. The goal of this study was to determine if a physiologic load could be used as an in situ osteogenic signal to the scaffolds filling the bone defects. In order to a ...

Taylor & Francis2014

Surgical preparation of bone-scaffold interface is critical for bone regeneration inside tissue engineering scaffold

Dominique Pioletti, Alireza Roshan Ghias

The goal of this study was to investigate if the preparation of implantation site has an impact on bone formation inside tissue engineering scaffolds. For this purpose, two different drilling techniques were used to create a hole in distal femurs of rats b ...

Wiley-Blackwell2011

Cellular biodegradable polymer nanocomposite scaffolds

Dominique Pioletti, Pierre-Etienne Bourban, John Christopher Plummer, Alireza Roshan Ghias, Claire Diane Delabarde

2011

Biodegradable Polymer Nanocomposite Scaffolds for Bone Replacement

Dominique Pioletti, Pierre-Etienne Bourban, John Christopher Plummer, Alireza Roshan Ghias, Claire Diane Delabarde

2011

In vivo loading increases mechanical properties of scaffold by affecting bone formation and bone resorption rates

Dominique Pioletti, Alireza Roshan Ghias

A successful bone tissue engineering strategy entails producing bone-scaffold construct with adequate mechanical properties. Apart from the mechanical properties of the scaffold itself, the forming bone inside the scaffold also adds to the strength of the ...

2011

Prediction of spatio-temporal bone formation in scaffold by diffusion equation

Dominique Pioletti, Lalaonirina Rakotomanana Ravelonarivo, Alireza Roshan Ghias, Arne Christian Vogel

Developing a successful bone tissue engineering strategy entails translation of experimental findings to clinical needs. A major leap forward towards this goal is developing a quantitative tool to predict spatial and temporal bone formation in scaffold. We ...

2011

In vivo assessment of local effects after application of bone screws delivering bisphosphonates into a compromised cancellous bone site

Dominique Pioletti, Alireza Roshan Ghias

Background: The primary stability of cancellous screw is difficult to obtain in bone of compromised quality and failure of screw fixation is common. To overcome this problem, it is proposed to locally deliver bisphosphonate from the screw An in vivo valida ...

Elsevier2011

Biomechanical Aspects of Osteogenesis in Load-Bearing Tissue Engineering Scaffolds

Alireza Roshan Ghias

There is increasing evidence that mechanical stimulation affects the fate of tissue engineering scaffolds. In clinical situations, it is critical to accelerate bone formation inside the scaffold to reduce the recovery time and increase the chance of succes ...

EPFL2011

In vivo cyclic loading as a potent stimulatory signal for bone formation inside tissue engineering scaffolds

Dominique Pioletti, Alexandre Terrier, Pierre-Etienne Bourban, Alireza Roshan Ghias

In clinical situations, bone defects are often located at load bearing sites. Tissue engineering scaffolds are future bone substitutes and hence they will be subjected to mechanical stimulation. The goal of this study was to test if cyclic loading can be u ...

European Cells & Materials Ltd2010

Biomechanical evaluation of porous biodegradable scaffolds for revision knee arthroplasty

Dominique Pioletti, Alexandre Terrier, Alireza Roshan Ghias, Marjan Sedighi Gilani, Line Aschwanden

Tibial bone defect is a critical problem for revision knee arthroplasty. Instead of using metallic spacer or cement, biodegradable scaffolds could be an alternative solution. A numerical model of a revision knee arthroplasty was thus developed to estimate ...

2009