Publications by Marc Gauthier | EPFL Graph Search

Arginine-specific protein modification using alpha-oxo-aldehyde functional polymers prepared by atom transfer radical polymerization

Harm-Anton Klok, Maxime Ayer, Frederik Roman Wurm, Marc Gauthier, Justyna Kowal

The residue-specific modification of peptides and proteins is a powerful strategy for preparing biomolecular-synthetic polymer conjugates with advanced properties. This manuscript aims at expanding the present toolbox of residue-selective protein modificat ...

2011

Arginine-Specific Modification of Proteins with Polyethylene Glycol

Harm-Anton Klok, Marc Gauthier

In this study, the residue-selective modification of proteins with polymers at arginine residues is reported. The difficulty in modifying arginine residues lies in the fact that they are less reactive than lysine residues. Consequently, typical chemo-selec ...

American Chemical Society2011

Polymer–protein conjugates: an enzymatic activity perspective

Harm-Anton Klok, Marc Gauthier

Proteins have been modified with polymers in diverse manners over the past 30 years. However, while proteins have been used to prepare many functional constructs, they are sensitive biomolecules and their bioactivity can be either positively or negatively ...

2010

Synthesis of functional polymers by post-polymerization modification

Harm-Anton Klok, Matthew Gibson, Marc Gauthier

(Figure Presented) Post-polymerization modification is based on the direct polymerization or copolymerization of monomers bearing chemoselective handles that are inert towards the polymerization conditions but can be quantitatively converted in a subsequen ...

Wiley-VCH Verlag GmbH2009

Synthesis of functional polymers by post-polymerization modification

Harm-Anton Klok, Matthew Gibson, Marc Gauthier

2009

Peptide/protein – polymer conjugates: synthetic strategies and design concepts

Harm-Anton Klok, Marc Gauthier

This feature article provides a compilation of tools available for preparing well-defined peptide/protein–polymer conjugates, which are defined as hybrid constructs combining (i) a defined number of peptide/protein segments with uniform chain lengths and d ...

Royal Society of Chemistry2008