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Luca Pellegrinet

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Related publications (4)

Please note that this is not a complete list of this person’s publications. It includes only semantically relevant works. For a full list, please refer to Infoscience.

Generation and characterization of a Notch1 signaling-specific reporter mouse line

Freddy Radtke, Yann Barrandon, Rajwinder Lehal, Stéphanie Claudinot, Luca Pellegrinet

Signaling through the Notch1 receptor is essential for the control of numerous developmental processes during embryonic life as well as in adult tissue homeostasis and disease. Since the outcome of Notch1 signaling is highly context-dependent, and its prec ...

Wiley-Blackwell2012

The Intestinal Epithelium : Role of Notch Signaling

Luca Pellegrinet

The mammalian intestine is a prototype of a self-renewing organ. The rapid cellular turnover is supported by proliferating progenitors located in the intestinal crypt, which is also the stem cell location. Homeostasis of the intestinal epithelium has to be ...

EPFL2011

Dll1- and Dll4-mediated Notch signaling is required for homeostasis of intestinal stem cells

Freddy Radtke, Ute Koch, Luca Pellegrinet, Shuang Chen

BACKGROUND & AIMS: Ablation of Notch signaling within the intestinal epithelium results in loss of proliferating crypt progenitors, due to their conversion into post-mitotic secretory cells. We aimed to confirm that Notch was active in stem cells (SC), inv ...

2011