Stewart Cole

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Related publications (489)

Tuberculosis: from genome to vaccine

Stewart Cole

The availability of mycobacterial genome sequences has paved the way to identifying potential tuberculosis vaccine candidates in order to replace the currently used bacillus Calmette-Guérin (BCG) vaccines that show variable protective efficacy in adults. G ...

2005

Observation of B̄0 → D0η′ and B̄0 → D*0η′

Stewart Cole, Tagir Aushev, Sun Hee Kim, Jing Li

We report the observation of B̄0 → D 0η′ and the first observation of B̄0 → D*0η′, using 140 fb-1 of data collected at the Y(4S) resonance with the Belle detector at the KEKB asymmetric energy e+e- collider. We find the branching fractions to be B(B̄0 → D0 ...

2005

Measurement of the branching fractions for B- → D ()+π-ℓ-v̄ℓ and B̄0 → D()0π+ℓ -v̄ℓ

Stewart Cole, Tagir Aushev, Vladislav Balagura, Sun Hee Kim

We report on a measurement of the branching fractions for B- → D()+π- ℓ -v̄ℓ and B̄0 → D ()0π+ℓ-v̄ℓ with 275 × 106 BB̄ events collected at the γ(4S) resonance with the Belle detector at KEKB. Events are tagged by fully reconstructing one of the B mesons ...

2005

Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans: the contribution of endogenous mycolactone toxin

Stewart Cole

Mycobacterium ulcerans (Mu), the aetiological agent of Buruli ulcer, is an extracellular pathogen producing the macrolide toxin mycolactone. Using a mouse model of intradermal infection, we found that Mu was initially captured by phagocytes and transported ...

2005

Differential effects of prior exposure to environmental mycobacteria on vaccination with Mycobacterium bovis BCG or a recombinant BCG strain expressing RD1 antigens

Stewart Cole

In silico analysis reveals that most protective antigens expressed by the antituberculous vaccine Mycobacterium bovis BCG (BCG) are conserved in M. avium, supporting the hypothesis that exposure to environmental mycobacteria generates cross-reactive immune ...

2005

Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis

Stewart Cole

The TB Vaccine Cluster project funded by the EU Fifth Framework programme aims to provide novel vaccines against tuberculosis that are suitable for evaluation in humans. This paper describes the studies of the protective efficacy of vaccines in a guinea pi ...

2005

Introduction to functional genomics of the Mycobacterium tuberculosis Complex

Stewart Cole

ASM Press2005

Mycobacterium ulcerans was first identified as the causative agent of Buruli ulcer; this cutaneous tissue-destructive process represents the third most important mycobacterial disease in humans after tuberculosis and leprosy. More recently other life trait ...

2005

The presence of a 174 kb plasmid called pMUM001 in Mycobacterium ulcerans, the first example of a mycobacterial plasmid encoding a virulence determinant, was recently reported. Over half of pMUM001 is devoted to six genes, three of which encode giant polyk ...

2005

Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans

Stewart Cole

The 174-kb virulence plasmid pMUM001 in Mycobacterium ulcerans epidemic strain Agy99 harbors three very large and homologous genes that encode giant polyketide synthases (PKS) responsible for the synthesis of the lipid toxin mycolactone. Deeper investigati ...

2005

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