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Keng Cher Soh

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Related publications (29)

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Summary: pyTFA and matTFA are the first published implementations of the original TFA paper. Specifically, they include explicit formulation of Gibbs energies and metabolite concentrations, which enables straightforward integration of metabolite concentrat ...

2018

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Reaction atom mappings track the positional changes of all of the atoms between the substrates and the products as they undergo the biochemical transformation. However, information on atom transitions in the context of metabolic pathways is not widely avai ...

Wiley-V C H Verlag Gmbh2017

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Recent advancements in omics measurement technologies have led to an ever-increasing amount of available experimental data that necessitate systems-oriented methodologies for efficient and systematic integration of data into consistent large-scale kinetic ...

2017

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Rational metabolic engineering methods are increasingly employed in designing the commercially viable processes for the production of chemicals relevant to pharmaceutical, biotechnology, and food and beverage industries. With the growing availability of om ...

Elsevier2016

Exploring enhancement of 1,4-butanediol production in recombinant E. coli using large-scale kinetic models

Vassily Hatzimanikatis, Ljubisa Miskovic, Keng Cher Soh, Anirikh Chakrabarti, Stefano Andreozzi

Engineering of microbial cell factories requires a simultaneous optimization of several criteria such as productivity, yield, titer, stress tolerance, all the while retaining the efficient, cost-effective and robust process. One of the most prominent examp ...

2015

Systematic Reduction of Genome Scale Metabolic Reconstructions - redGEM

Vassily Hatzimanikatis, Meriç Ataman, Georgios Fengos, Keng Cher Soh, Daniel Federico Hernandez Gardiol

Genome-scale metabolic reconstructions (GEMs) are valuable resources for understanding and redesigning cellular networks as they encapsulate all the known biochemistry of the organisms from genes to proteins to their functions. Complexity of these large me ...

2015

Systematic Reduction of Genome Scale Metabolic Reconstructions - redGEM

Vassily Hatzimanikatis, Meriç Ataman, Georgios Fengos, Keng Cher Soh, Daniel Federico Hernandez Gardiol

2015

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Lipids are important compounds for human physiology and as renewable resources for fuels and chemicals. In lipid research, there is a big gap between the currently available pathway-level representations of lipids and lipid structure databases in which the ...

Academic Press Inc Elsevier Science2014

A Novel Approach to Design of Metabolic Engineering Strategiesa

Vassily Hatzimanikatis, Ljubisa Miskovic, Meriç Ataman, Georgios Fengos, Keng Cher Soh, Anirikh Chakrabarti

Dynamic nonlinear models of metabolism offer significant advantages as compared to traditional steady-state counterparts for the analysis of metabolic networks and identification of metabolic engineering strategies. Uncertainties in the metabolic network s ...

2014

Engineering improved productivity of 1,4-butanediol in E. coli – a kinetic modeling approach

Vassily Hatzimanikatis, Ljubisa Miskovic, Keng Cher Soh, Anirikh Chakrabarti, Stefano Andreozzi

Microbial cell factories are becoming a norm for commercially viable production of chemicals for pharmaceutical, biotechnology, food and beverage industries. However, engineering of microbial cell factories requires a simultaneous optimization of several c ...

2014