Publications by Bruno Lemaitre

Bacterial-induced Duox-ROS regulates the Imd immune pathway in the gut by modulating the peritrophic matrix

The Duox-reactive oxygen species (ROS) system and the immune deficiency (Imd) pathway play a major role in insect gut immunity. However, their interaction to accomplish an effective immune response is still unclear. Here, we show that Duox regulates the pe ...

2025

An updated proteomic analysis of Drosophila haemolymph after bacterial infection

Bruno Lemaitre, Samuel Rommelaere, Fanny Schüpfer

Using an in-depth Mass Spectrometry-based proteomics approach, we provide a comprehensive characterization of the hemolymphatic proteome of adult flies upon bacterial infection. We detected and quantified changes in abundance of several known immune regula ...

2025

The secreted Nimrod protein NimB1 negatively regulates early steps of apoptotic cell phagocytosis in Drosophila

Bruno Lemaitre, Samuel Rommelaere, Bianca Marie Petrignani

Efferocytosis, the efficient clearance of apoptotic cells (ACs) by phagocytes, is vital for maintaining tissue homeostasis. Here, we reveal the role of the secreted protein NimB1 in reducing apoptotic cell recognition and binding in the early stages of eff ...

2025

Gut commensal bacteria-derived methionine is required for host reproduction by modulating RNA m6A methylation of the insulin receptor

Bruno Lemaitre

Gut commensal bacteria promote host reproduction by modulating metabolism and nutrition, but the molecular mechanisms by which microbes regulate reproduction remain unclear. Here, we show that gut commensal bacteria promote host reproduction by providing t ...

2025

SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response

Bruno Lemaitre

During parasitoid wasp infection, activated immune cells of Drosophila melanogaster larvae release adenosine to conserve nutrients for immune response. S-adenosylmethionine (SAM) is a methyl group donor for most methylations in the cell and is synthesized ...

eLife Sciences Publications, Ltd2025

Pathobiont and symbiont contribute to microbiota homeostasis through Malpighian tubules–gut countercurrent flow in Bactrocera dorsalis

Bruno Lemaitre

Host–gut microbiota interactions are more complex than good or bad. Both gut symbiotic bacteria and pathobionts can provide essential functions to their host in one scenario and yet be detrimental to host health in another. So, these gut-dwelling bacteria ...

2024

The Drosophila immunity handbook

Bruno Lemaitre, Mark Austin Hanson

Animals possess efficient mechanisms for detecting and neutralizing infection. The application of Drosophila genetics to the study of these mechanisms has generated insights into insect immunity and uncovered general principles of animal host defense. Thes ...

EPFL Press2024

Duox activation in Drosophila Malpighian tubules stimulates intestinal epithelial renewal through a countercurrent flow

Bruno Lemaitre, Xiaoxue Li

The gut must perform a dual role of protecting the host against toxins and pathogens while harboring mutualistic microbiota. Previous studies suggested that the NADPH oxidase Duox contributes to intestinal homeostasis in Drosophila by producing reactive ox ...

Elsevier BV2024

Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion

Bruno Lemaitre, Zongzhao Zhai

Amino acid availability is monitored by animals to adapt to their nutritional environment. Beyond gustatory receptors and systemic amino acid sensors, enteroendocrine cells (EECs) are believed to directly percept dietary amino acids and secrete regulatory ...

Nature Portfolio2024

A humoral stress response protects Drosophila tissues from antimicrobial peptides

Bruno Lemaitre, Matteo Dal Peraro, Jean Philippe Boquete, Chan Cao, Samuel Rommelaere, Fernando Augusto Teixeira Pinto Meireles, Alexia Laurie Carboni

An efficient immune system must provide protection against a broad range of pathogens without causing excessive collateral tissue damage. While immune effectors have been well characterized, we know less about the resilience mechanisms protecting the host ...

Elsevier BV2024