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Alexandra Marie-Isabelle Karoline Brigitte Magold

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Related publications (3)

Please note that this is not a complete list of this person’s publications. It includes only semantically relevant works. For a full list, please refer to Infoscience.

Gene expression profiling in cells with enhanced gamma-secretase activity

Patrick Fraering, Alexandra Marie-Isabelle Karoline Brigitte Magold

BACKGROUND: Processing by gamma-secretase of many type-I membrane protein substrates triggers signaling cascades by releasing intracellular domains (ICDs) that, following nuclear translocation, modulate the transcription of different genes regulating a div ...

Public Library of Science2009

Gamma-Secretase Dependent Gene Expression : a Potential New Focus of Alzheimer's Disease Research

Alexandra Marie-Isabelle Karoline Brigitte Magold

The causes of sporadic Alzheimer's Disease (AD), the most common form of dementia at old age, are still unknown. Familial early onset AD (FAD) is mainly caused by mutations of Presenilins (PS), the active subunits of γ-secretase. Processing of its substrat ...

EPFL2011

Gamma-Secretase activity alterations affect Wnt pathway gene transcription in CHO cells

Alexandra Marie-Isabelle Karoline Brigitte Magold, Patrick Fraering

Elsevier2011