Daniel Ortiz Trujillo

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Related publications (23)

DNA as a Recyclable Natural Polymer

Francesco Stellacci, Daniel Ortiz Trujillo, Weina Liu, Simone Giaveri

Nature has the ability of circularly re-using its components to produce the molecules and materials it needs. An example is the ability of most living organisms of digesting proteins they feed off into amino acids and then using such amino acids in the rib ...

WILEY-V C H VERLAG GMBH2022

Dysfunction of the circadian clock in the kidney tubule leads to enhanced kidney gluconeogenesis and exacerbated hyperglycemia in diabetes

Laure Menin, Daniel Ortiz Trujillo, Hikari Ananda Infinity Yoshihara

The circadian clock is a ubiquitous molecular time-keeping mechanism which synchronizes cellular, tissue, and systemic biological functions with 24-hour environmental cycles. Local circadian clocks drive cell type- and tissuespecific rhythms and their dysr ...

2022

On-Demand Nanoliter Sampling Probe for the Collection of Brain Fluid

Philippe Renaud, Hilal Lashuel, Arnaud Bertsch, Laure Menin, Daniel Ortiz Trujillo, Joan Teixidor, Salvatore Novello

Continuous fluidic sampling systems allow collection of brain biomarkers in vivo. Here, we propose a new sequential and intermittent sampling paradigm using droplets, called Droplet on Demand (DoD). It is implemented in a microfabricated neural probe and a ...

AMER CHEMICAL SOC2022

Nature-Inspired Circular-Economy Recycling for Proteins: Proof of Concept

Francesco Stellacci, Laure Menin, Luc Patiny, Shiyu Cheng, Daniel Ortiz Trujillo, Anna Murello, Simone Giaveri

The billion tons of synthetic-polymer-based materials (i.e. plastics) produced yearly are a great challenge for humanity. Nature produces even more natural polymers, yet they are sustainable. Proteins are sequence-defined natural polymers that are constant ...

Wiley2021

Modified cyclodextrins as broad-spectrum antivirals

Francesco Stellacci, Natalia Gasilova, Daniel Ortiz Trujillo, Valeria Cagno, Matteo Gasbarri, Samuel Thomas Jones, Matej Janecek

Viral infections kill millions of people and new antivirals are needed. Nontoxic drugs that irreversibly inhibit viruses (virucidal) are postulated to be ideal. Unfortunately, all virucidal molecules described to date are cytotoxic. We recently developed n ...

AMER ASSOC ADVANCEMENT SCIENCE2020

Aom(2)S: A new web-based application for DNA/RNA tandem mass spectrometry data interpretation

Paul Joseph Dyson, Natalia Gasilova, Laure Menin, Luc Patiny, Daniel Ortiz Trujillo, Francisco Sepulveda

Rationale The Analysis of Oligonucleotide Modifications from Mass Spectra (Aom(2)S) was created to support the analysis of oligonucleotide mass spectra. This application complements the existing software tools by providing a comprehensive analysis of oligo ...

WILEY2020

Boronate Ester-Capped Helicates

Rosario Scopelliti, Kay Severin, Farzaneh Fadaei Tirani, Daniel Ortiz Trujillo, Adrien Bryan Depallens, Erica Giraldi

Triple‐stranded helicates were obtained by metal‐templated multicomponent reactions of bispyridyloxime ligands with arylboronic acids. The helicates feature two hexa‐coordinated MII ions (M=Fe, Zn, or Mn), which are embedded in a macrobicyclic ligand frame ...

2020

Two-photon triggered photorelease of caged compounds from multifunctional harmonic nanoparticles

Sandrine Gerber, Laure Menin, Daniel Ortiz Trujillo, Jérémy Vuilleumier, Raphaël Jovita De Matos, Luigi Bonacina

The design of stimuli-responsive nanocarriers has raised much attention to achieve higher local concentration of therapeutics and mitigate the appearance of drug resistance. The combination of imaging properties and controlled photorelease of active molecu ...

2019

Histidine Targeting Heterobimetallic Ruthenium(II)-Gold(I) Complexes

Paul Joseph Dyson, Daniel Ortiz Trujillo, Lucinda Kate Batchelor

Inspired by the preferential, allosteric binding of RAPTA-T and auranofin to the nucleosome core particle, we describe the design and synthesis of a series of heterobimetallic ruthenium(II)-gold(I) complexes with varying spacer lengths ranging from four to ...

2019

Delineation of the Critical Parameters of Salt Catalysts in the N-Formylation of Amines with CO2

Paul Joseph Dyson, Daniel Ortiz Trujillo, Martin Hulla, Dmitry Vasilyev

N-formylation of amines with CO2 is base-catalyzed and studies of salt catalysts reveal that the reaction is efficiently catalyzed by "free" floating anions of high basicity, as represented in the cover image. More information can be found in the Full Pape ...

WILEY-V C H VERLAG GMBH2019

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