Publications by Jérôme Waser

Photomediated aliphatic C-H functionalization

The C–H functionalization of inert alkanes has long been one of the most challenging reactions in organic synthesis. Now, the use of hypervalent iodine reagents has enabled the diverse functionalization of various aliphatic C–H bonds under blue light irrad ...

NATURE PORTFOLIO2025

Enantioselective Synthesis of 1,2-disubstituted Thiocyclobutanes via Michael Addition

Jérôme Waser, Emma Gabrielle Louise Robert

We report the diastereoselective and enantioselective synthesis of thio-substituted cyclobutanes via a sulfa-Michael addition using cyclobutenes. In the presence of DBU, various thio-cyclobutane esters and amides were obtained in up to quantitative yield a ...

ROYAL SOC CHEMISTRY2025

Beginning of Second Mandate as Editors-in-Chief for Helvetica Chimica Acta

Jérôme Waser

The beginning of 2025 marks the completion of our first 3-year mandate as Editors-in-Chief of Helvetica Chimica Acta. This has been an exciting and intensive period of time, which has allowed us to drive forward our vision for the journal. We are now delig ...

2025

Unlocking σ-Type Cyclopropenium Cation Transfer Reactions by an Iodine(III)-Based Umpolung Strategy

Jérôme Waser, Xiangdong Li

sigma-Type cyclopropenium cations (CPCs), which are formally generated by removing one substituent on the alkene of cyclopropenes, represent promising intermediates for forging functionalized cyclopropenes. However, sigma-type CPCs are challenging to acces ...

GEORG THIEME VERLAG KG2025

Synthesis of Bicyclo[1.1.1]pentane Z‐Substituted Enamides, Enol Ethers, and Vinyl Sulfides Using Iodine (III) Reagents

Jérôme Waser, Elija Grinhagena

Bicyclo[1.1.1]pentanes (BCPs) are well‐studied bioisosteres for para‐substituted benzene rings and numerous methods for synthesizing 1,3‐difunctionalized BCPs have been developed. However, synthetic approaches to access vinyl BCP motifs remain limited, wit ...

Wiley2025

Peptide‐Carbazolyl Cyanobenzene Conjugates: Enabling Biomolecule Functionalization via Photoredox and Energy Transfer Catalysis

Jérôme Waser, Beat Fierz, Anne-Sophie Chauvin, Wei Cai, Xingyu Liu

Since their discovery in 2012, carbazolyl (iso)phthalonitrile derivatives (Cz(I)PN) have found significant applications as photocatalysts in organic chemistry. Herein, we introduce two efficient methods for incorporating carbazolyl cyanobenzenes into vario ...

Wiley2025

The Azidofunctionalization of Alkenes

Jérôme Waser, Pierre Gérard Joseph Palamini

The azidofunctionalization of alkenes has emerged as a powerful difunctionalization strategy, expanding the toolbox of synthetic chemistry. This transformation enables the simultaneous installation of an azide and a second functional group onto an alkene, ...

Wiley2025

Photocatalyzed Azidofunctionalization of Alkenes via Radical-Polar Crossover

Jérôme Waser, Pierre Gérard Joseph Palamini, Alexandre Alain Schöpfer

The azidofunctionalization of alkenes under mild conditions using commercially available starting materials and easily accessible reagents is reported based on a radical-polar crossover strategy. A broad range of alkenes, including vinyl arenes, enamides, ...

Wiley2025

Accessing elusive σ-type cyclopropenium cation equivalents through redox gold catalysis

Jérôme Waser, Matthew Wodrich, Xiangdong Li

Cyclopropenes are the smallest unsaturated carbocycles. Removing one substituent from cyclopropenes leads to cyclopropenium cations (C3 + systems, CPCs). Stable aromatic pi-type CPCs were discovered by Breslow in 1957 by removing a substituent on the aliph ...

2024

Silylium-Catalyzed Activation of DonorAcceptor Strained Rings and Annulation with Indoles

Jérôme Waser, Emma Gabrielle Louise Robert

: Leveraging the unique reactivity profile of donor -acceptor aminocyclopropanes and cyclobutanes allows the preparation of complex nitrogen -substituted molecules. While most reports focus on donor -acceptor strained rings with two geminal carbonyl groups ...

Swiss Chemical Soc2024