Person
Sophie Redon
This person is no longer with EPFL
Related publications (8)
Quantitative telomeric chromatin isolation protocol for human cells
Joachim Lingner, Jana Majerská, Sophie Redon
The ends of eukaryotic chromosomes, known as telomeres, consist of repetitive DNA sequences, multiple proteins and noncoding RNAs. Telomeres are dynamic structures that play crucial roles as guardians of genome stability and tumor suppressors. Defects in t ...
2017Peroxiredoxin 1 Protects Telomeres from Oxidative Damage and Preserves Telomeric DNA for Extension by Telomerase
Joachim Lingner, Viesturs Simanis, Sophie Redon, Wareed Ahmed, Eric Aeby
Oxidative damage of telomeres can promote cancer, cardiac failure, and muscular dystrophy. Specific mechanisms protecting telomeres from oxidative damage have not been described. We analyzed telomeric chromatin composition during the cell cycle and show th ...
Elsevier2016A three-state model for the regulation of telomerase by TERRA and hnRNPA1
Joachim Lingner, Sophie Redon, Ivo Zemp
Telomeres, the physical ends of eukaryotic chromosomes, are transcribed into telomeric repeat-containing RNA (TERRA), a large non-coding RNA, which forms an integral part of telomeric heterochromatin. In vitro, naked TERRA molecules are efficient inhibitor ...
Oxford University Press2013The human CST complex is a terminator of telomerase activity
Joachim Lingner, Sophie Redon, Liuh-Yow Chen
The lengths of human telomeres, which protect chromosome ends from degradation and end fusions(1,2), are crucial determinants of cell lifespan(3). During embryogenesis and in cancer, the telomerase enzyme counteracts telomeric DNA shortening. As shown in c ...
Nature Publishing Group2012Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast
Joachim Lingner, Sophie Redon, Verena Pfeiffer, Nahid Iglesias
Telomeric repeat-containing RNA (TERRA) has been implicated in the control of heterochromatin and telomerase. We demonstrate that yeast TERRA is regulated by telomere-binding proteins in a chromosome-end-specific manner that is dependent on subtelomeric re ...
2011The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase
Telomeres, the physical ends of eukaryotes chromosomes are transcribed into telomeric repeat containing RNA (TERRA), a large non-coding RNA of unknown function, which forms an integral part of telomeric heterochromatin. TERRA molecules resemble in sequence ...
Oxford University Press2010The Rat1p 5’ to 3’ exonuclease degrades telomeric repeat-containing RNA and promotes telomere elongation in Saccharomyces cerevisiae
Joachim Lingner, Sophie Redon, Andrea Bernardo Panza, Nahid Iglesias
Vertebrate telomeres are transcribed into telomeric repeat-containing RNA (TERRA) that associates with telomeres and may be important for telomere function. Here, we demonstrate that telomeres are also transcribed in Saccharomyces cerevisiae by RNA polymer ...
2008Protein-RNA and protein-protein interactions mediate association of human EST1A/SMG6 with telomerase
The human EST1A/SMG6 polypeptide physically interacts with the chromosome end replication enzyme telomerase. In an attempt to better understand hEST1A function, we have started to dissect the molecular interactions between hEST1A and telomerase. Here, we d ...
2007