Publications by David Welchman

Negative Regulation by Amidase PGRPs Shapes the Drosophila Antibacterial Response and Protects the Fly from Innocuous Infection

Bruno Lemaitre, Juan Camilo Paredes Escobar, David Welchman

Peptidoglycan recognition proteins (PGRPs) are key regulators of insect immune responses. In addition to recognition PGRPs, which activate the Toll and Imd pathways, the Drosophila genome encodes six catalytic PGRPs with the capacity to scavenge peptidogly ...

2011

Drosophila immunity: analysis of PGRP-SB1 expression, enzymatic activity and function

Bruno Lemaitre, Juan Camilo Paredes Escobar, David Welchman

Peptidoglycan is an essential and specific component of the bacterial cell wall and therefore is an ideal recognition signature for the immune system. Peptidoglycan recognition proteins (PGRPs) are conserved from insects to mammals and able to bind PGN (no ...

Public Library of Science2011

Long-range activation of systemic immunity through peptidoglycan diffusion in Drosophila

Bruno Lemaitre, David Welchman

The systemic immune response of Drosophila is known to be induced both by septic injury and by oral infection with certain bacteria, and is characterized by the secretion of antimicrobial peptides (AMPs) into the haemolymph. To investigate other possible r ...

2009

Cell shape changes indicate a role for extrinsic tensile forces in Drosophila germ-band extension

David Welchman

Drosophila germ-band extension (GBE) is an example of the convergence and extension movements that elongate and narrow embryonic tissues. To understand the collective cell behaviours underlying tissue morphogenesis, we have continuously quantified cell int ...

2009

Insect immunity: from pattern recognition to symbiont-mediated host defense

Bruno Lemaitre, David Welchman

The Jacques Monod conference "Insect Immunity in Action: From Fundamental Mechanisms of Host Defense to Resistance Against Infections in Nature," organized by Ulrich Theopold (Stockholm University, Sweden) and Dominique Ferrandon (CNRS, France), was held i ...

2009