Person
Pablo Campomanes Ramos
This person is no longer with EPFL
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Related publications (22)
Please note that this is not a complete list of this person’s publications. It includes only semantically relevant works. For a full list, please refer to Infoscience.
An Atomistic Look into Bio-inspired Nanoparticles and their Molecular Interactions with Cells
Francesco Stellacci, Alke Fink, Pablo Campomanes Ramos, Stefano Vanni
Nanoparticles (NPs) have sizes that approach those of pathogens and they can interact with the membranes of eukaryotic cells in an analogous fashion. Typically, NPs are taken up by the cell via the plasma membrane by receptor-mediated processes and subsequ ...
SWISS CHEMICAL SOC2019Anandamide Hydrolysis in FAAH Reveals a Dual Strategy for Efficient Enzyme-Assisted Amide Bond Cleavage via Nitrogen Inversion
Ursula Röthlisberger, Andrea Cavalli, Pablo Campomanes Ramos, Giulia Palermo
Herein, we combined classical molecular dynamics (MD) and quantum mechanical/molecular mechanics (QM/MM) simulations to unravel the whole catalytic cycle of fatty acid amide hydrolase (FAAH) in complex with anandamide, the main neurotransmitters involved i ...
2015Keys to Lipid Selection in Fatty Acid Amide Hydrolase Catalysis: Structural Flexibility, Gating Residues and Multiple Binding Pockets
Ursula Röthlisberger, Andrea Cavalli, Pablo Campomanes Ramos, Giulia Palermo
The fatty acid amide hydrolase (FAAH) regulates the endocannabinoid system cleaving primarily the lipid messenger anandamide. FAAH has been well characterized over the years and, importantly, it represents a promising drug target to treat several diseases, ...
2015