Person
Nicola Vannini
This person is no longer with EPFL
Related publications (6)
Disturbed mitochondrial dynamics in CD8(+)TILs reinforce T cell exhaustion
Li Tang, George Coukos, Marcela Rincón-Restrepo, Nicola Vannini, Min Gao, Fabien Franco
Ho and colleagues report that mitochondrial dysfunction and impaired mitophagy triggered by the tumor microenvironment lead to subsequent epigenetic changes and cause permanent T cell exhaustion and dysfunction. The metabolic challenges present in tumors a ...
2020Specification of haematopoietic stem cell fate via modulation of mitochondrial activity
Johan Auwerx, Matthias Lütolf, Olaia Maria Naveiras Torres-Quiroga, Aline Roch, Vasco Ledebur de Antas de Campos, Mukul Girotra, Nicola Vannini, Gennady Nikitin, Sonja Giger
Haematopoietic stem cells (HSCs) differ from their committed progeny by relying primarily on anaerobic glycolysis rather than mitochondrial oxidative phosphorylation for energy production. However, whether this change in the metabolic program is the cause ...
Nature Publishing Group2016