Kristina Schoonjans

Related publications (185)

About
Privacy
Disclaimer

Related publications (185)

Deconstructing bile acid signaling pathways

Johan Auwerx, Kristina Schoonjans

American Chemical Society2011

Histone methyl transferases and demethylases; can they link metabolism and transcription?

Johan Auwerx, Kristina Schoonjans

Heritable changes to the transcriptome that are independent to changes in the genome are defined as epigenetics. DNA methylation and posttranslational modifications of histones, such as acetylation/deacetylation and methylation/demethylation of lysine resi ...

Elsevier2010

Lipopolysaccharide induces intestinal glucocorticoid synthesis in a TNFalpha-dependent manner

Kristina Schoonjans

Stringent control of immune responses in the intestinal mucosa is critical for the maintenance of immune homeostasis and prevention of tissue damage, such as observed during inflammatory bowel disease. Intestinal epithelial cells, primarily thought to form ...

2010

Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility

Johan Auwerx, Kristina Schoonjans, Ellen Helena Jeninga

rganisms adapt their metabolism to meet ever changing environmental conditions. This metabolic adaptation involves at a cellular level the fine tuning of mitochondrial function, which is mainly under the control of the transcriptional co-activator prolifer ...

2010

, ,

Glucose-evoked mitochondrial signals augment ATP synthesis in the pancreatic β cell. This activation of energy metabolism increases the cytosolic ATP/ADP ratio, which stimulates plasma membrane electrical activity and insulin granule exocytosis. We have re ...

2010

The normal mechanisms of pregnancy-induced liver growth are not maintained in mice lacking the bile acid sensor Fxr

Kristina Schoonjans, Chikage Mataki

Milona A, Owen BM, van Mil S, Dormann D, Mataki C, Boudjelal M, Cairns W, Schoonjans K, Milligan S, Parker M, White R, Williamson C. The normal mechanisms of pregnancy-induced liver growth are not maintained in mice lacking the bile acid sensor Fxr. Am J P ...

2010

Raised hepatic bile acid concentrations during pregnancy in mice are associated with reduced farnesoid X receptor function

Kristina Schoonjans

Pregnancy alters bile acid homeostasis and can unmask cholestatic disease in genetically predisposed but otherwise asymptomatic individuals. In this report, we show that normal pregnant mice have raised hepatic bile acid levels in the presence of procholes ...

2010

The Intestinal Nuclear Receptor Signature With Epithelial Localization Patterns and Expression Modulation in Tumors

Johan Auwerx, Kristina Schoonjans

BACKGROUND & AIMS: The WNT-adenomatous polyposis coli system controls cell fate in the intestinal epithelium, where compartment-specific genes tightly regulate proliferation, migration, and differentiation. Nuclear receptors are transcription factors funct ...

2010

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

Johan Auwerx, Kristina Schoonjans, Thijs Pols

Incretin-based therapies have shown promise in the treatment of type 2 diabetes. Here we review our current understanding of TGR5 as a target to induce glucagon-like peptide-1 (GLP-1) secretion. These new observations suggest that TGR5 agonists may constit ...

Elsevier Masson2010

Redefining the TGR5 triterpenoid binding pocket at the C-3 position

Johan Auwerx, Kristina Schoonjans

Wiley-Blackwell2010

Page 11 of 19

Raised hepatic bile acid concentrations during pregnancy in mice are associated with reduced farnesoid X receptor function

Kristina Schoonjans

2010

, ,

2010

Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells

Kristina Schoonjans

Andreas Wiederkehr

Chikage Mataki